SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.03A 1v55C-1tuzA:
undetectable
1v55J-1tuzA:
undetectable		 1v55C-1tuzA:
16.86
1v55J-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.03A 2dysC-1tuzA:
undetectable
2dysJ-1tuzA:
undetectable		 2dysC-1tuzA:
16.86
2dysJ-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.01A 2dysP-1tuzA:
undetectable
2dysW-1tuzA:
undetectable		 2dysP-1tuzA:
16.86
2dysW-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.03A 2eijC-1tuzA:
undetectable
2eijJ-1tuzA:
undetectable		 2eijC-1tuzA:
16.86
2eijJ-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.03A 2eijP-1tuzA:
undetectable
2eijW-1tuzA:
undetectable		 2eijP-1tuzA:
16.86
2eijW-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.00A 2eimC-1tuzA:
undetectable
2eimJ-1tuzA:
undetectable		 2eimC-1tuzA:
16.86
2eimJ-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 6 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.09A 2einP-1tuzA:
undetectable
2einW-1tuzA:
undetectable		 2einP-1tuzA:
16.86
2einW-1tuzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 7 LEU A  74
GLN A  76
PHE A  75
LEU A  57
 None
 1.04A 3ag2C-1tuzA:
undetectable		 3ag2C-1tuzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 6 CYH A  95
PHE A  53
PHE A  78
PHE A 103
 None
 1.39A 3m0wB-1tuzA:
4.2
3m0wJ-1tuzA:
4.4		 3m0wB-1tuzA:
20.33
3m0wJ-1tuzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		3 / 3 PHE A  53
VAL A  94
GLU A  79
 None
 0.68A 4fvqA-1tuzA:
undetectable		 4fvqA-1tuzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		4 / 5 ASP A  98
VAL A  93
ASP A  92
GLY A  81
 None
 1.18A 4xp6A-1tuzA:
undetectable		 4xp6A-1tuzA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		5 / 12 SER A  77
LEU A  74
ILE A   8
PHE A  13
GLY A 108
 None
 1.08A 5veuB-1tuzA:
undetectable		 5veuB-1tuzA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1tuz DIACYLGLYCEROL
KINASE ALPHA
(Homo
sapiens) 		3 / 3 LEU A  31
VAL A  99
ASP A  98
 None
 0.65A 5x23A-1tuzA:
undetectable		 5x23A-1tuzA:
15.01