SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 7 LEU A 201
ILE A 214
ILE A 235
ASP A 209
 None
 0.72A 1uwjA-1tvcA:
undetectable		 1uwjA-1tvcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 5 PHE A 153
THR A 128
LEU A 246
ALA A 125
 None
None
FDA  A 252 (-4.1A)
None
 1.44A 2e1qD-1tvcA:
undetectable		 2e1qD-1tvcA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 3 SER A 248
GLU A 160
ASP A 189
 None
FDA  A 252 (-3.2A)
FDA  A 252 ( 4.2A)
 0.81A 2zthA-1tvcA:
4.9		 2zthA-1tvcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 3 PRO A 219
PHE A 242
LYS A 244
 None
 0.97A 3bjwG-1tvcA:
undetectable		 3bjwG-1tvcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 3 SER A 248
GLU A 160
ASP A 189
 None
FDA  A 252 (-3.2A)
FDA  A 252 ( 4.2A)
 0.76A 3bwmA-1tvcA:
4.1		 3bwmA-1tvcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 3 SER A 248
GLU A 160
ASP A 189
 None
FDA  A 252 (-3.2A)
FDA  A 252 ( 4.2A)
 0.84A 3bwyA-1tvcA:
4.2		 3bwyA-1tvcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 4 ARG A   3
ASP A  36
GLY A 106
THR A  54
 None
 1.13A 3k4vB-1tvcA:
undetectable		 3k4vB-1tvcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 8 SER A  61
THR A  58
LEU A 102
ALA A  96
 FDA  A 252 ( 4.8A)
None
None
None
 1.01A 3ns1L-1tvcA:
undetectable		 3ns1L-1tvcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		5 / 11 VAL A 110
GLY A 112
TYR A 215
ALA A 250
PHE A 245
 FDA  A 252 (-3.6A)
None
None
None
FDA  A 252 (-3.5A)
 1.44A 3qxyB-1tvcA:
0.0
3qxyQ-1tvcA:
undetectable		 3qxyB-1tvcA:
21.08
3qxyQ-1tvcA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 3 SER A 248
GLU A 160
ASP A 189
 None
FDA  A 252 (-3.2A)
FDA  A 252 ( 4.2A)
 0.78A 4xudA-1tvcA:
4.0		 4xudA-1tvcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 5 GLY A 188
SER A 248
GLU A 160
ASP A 189
 FDA  A 252 (-3.3A)
None
FDA  A 252 (-3.2A)
FDA  A 252 ( 4.2A)
 1.24A 4xueA-1tvcA:
3.8		 4xueA-1tvcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		3 / 5 GLY A 126
GLY A 192
GLU A 191
 None
 0.52A 4z2eA-1tvcA:
undetectable
4z2eD-1tvcA:
2.7		 4z2eA-1tvcA:
18.46
4z2eD-1tvcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		5 / 12 LEU A 170
ILE A 151
PHE A 123
ALA A 125
GLY A  48
 None
 1.06A 5veuB-1tvcA:
undetectable		 5veuB-1tvcA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1tvc METHANE
MONOOXYGENASE
COMPONENT C
(Methylococcus
capsulatus) 		4 / 5 GLY A 192
TRP A 184
VAL A 183
SER A 248
 None
 1.39A 5vunA-1tvcA:
undetectable		 5vunA-1tvcA:
22.10