SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 285
GLU A 281
LYS A 304
ILE A 302
PHE A 194
 None
 1.35A 1gx8A-1tveA:
0.0		 1gx8A-1tveA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 178
ASN A 319
GLN A 335
ASN A 182
 None
 1.14A 1rs6A-1tveA:
undetectable		 1rs6A-1tveA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 178
ASN A 319
GLN A 335
ASN A 182
 None
 1.16A 1rs6B-1tveA:
0.0		 1rs6B-1tveA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 120
LEU A 130
ASN A 116
ASP A  91
 None
 0.94A 1yc2E-1tveA:
2.9		 1yc2E-1tveA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  96
ILE A  98
ASN A 116
ASP A  91
 None
 1.09A 2h4jA-1tveA:
2.6		 2h4jA-1tveA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 110
THR A 114
PHE A 120
PHE A 131
 None
 1.34A 3em0A-1tveA:
undetectable		 3em0A-1tveA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A 225
ASN A 216
LEU A 218
GLY A 217
PHE A 241
 None
 1.36A 3h9uB-1tveA:
3.4		 3h9uB-1tveA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 102
ILE A 153
ALA A 144
THR A 145
ILE A 226
 None
 1.10A 3ndiA-1tveA:
undetectable		 3ndiA-1tveA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 283
ASN A 182
ASP A 306
 None
 0.73A 4o1eA-1tveA:
undetectable		 4o1eA-1tveA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 147
GLU A 143
VAL A 227
LEU A 156
ILE A 334
 None
 1.09A 4pd9A-1tveA:
0.0		 4pd9A-1tveA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 341
THR A 344
ALA A 342
GLY A  14
ASP A  22
 None
 1.20A 4qvnK-1tveA:
undetectable
4qvnL-1tveA:
undetectable		 4qvnK-1tveA:
19.83
4qvnL-1tveA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 341
THR A 344
ALA A 342
GLY A  14
ASP A  22
 None
 1.20A 4qvnY-1tveA:
undetectable
4qvnZ-1tveA:
undetectable		 4qvnY-1tveA:
19.83
4qvnZ-1tveA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 341
THR A 344
ALA A 342
GLY A  14
ASP A  22
 None
 1.20A 4qvqY-1tveA:
undetectable
4qvqZ-1tveA:
undetectable		 4qvqY-1tveA:
19.83
4qvqZ-1tveA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 190
VAL A 284
LEU A 285
PHE A 194
 None
 0.82A 4r38A-1tveA:
undetectable		 4r38A-1tveA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 190
VAL A 284
LEU A 285
PHE A 194
 None
 0.84A 4r38D-1tveA:
undetectable		 4r38D-1tveA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 190
VAL A 284
LEU A 285
PHE A 194
 None
 0.89A 4r3aA-1tveA:
undetectable		 4r3aA-1tveA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 289
LEU A 156
PHE A 155
ILE A 323
 None
 0.71A 4xv2A-1tveA:
undetectable		 4xv2A-1tveA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 198
SER A 195
ASP A 196
PRO A 211
LEU A 215
 None
 1.49A 5jh7B-1tveA:
undetectable		 5jh7B-1tveA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 153
ILE A 230
ILE A 169
ILE A 321
ILE A 323
 None
 1.02A 5murE-1tveA:
undetectable		 5murE-1tveA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  37
LEU A  38
TRP A  59
 None
 0.75A 5nwuA-1tveA:
0.0		 5nwuA-1tveA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 225
ASN A 216
LEU A 218
GLY A 217
PHE A 241
 None
 1.37A 6exiA-1tveA:
2.3		 6exiA-1tveA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  12
GLY A  14
GLU A  40
THR A  93
ILE A  98
 None
 0.68A 6exiA-1tveA:
4.3		 6exiA-1tveA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  12
GLY A  14
GLU A  40
THR A  93
ILE A  98
 None
 0.65A 6exiB-1tveA:
undetectable		 6exiB-1tveA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  12
GLY A  14
GLU A  40
THR A  93
ILE A  98
 None
 0.67A 6exiC-1tveA:
2.5
6exiD-1tveA:
2.4		 6exiC-1tveA:
17.13
6exiD-1tveA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1tve HOMOSERINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  12
GLY A  14
GLU A  40
THR A  93
ILE A  98
 None
 0.68A 6exiC-1tveA:
2.5
6exiD-1tveA:
2.5		 6exiC-1tveA:
17.13
6exiD-1tveA:
17.13