SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 ILE A 189
ALA A 217
LEU A   5
THR A 221
ILE A  96
 None
 1.03A 1ddrA-1tvpA:
undetectable		 1ddrA-1tvpA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 ILE A 189
ALA A 217
LEU A   5
THR A 221
ILE A  96
 None
 1.09A 1ddsA-1tvpA:
undetectable		 1ddsA-1tvpA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 ASN A 227
GLU A 238
HIS A 200
TYR A 204
ARG A 205
 None
None
EPE  A 700 (-4.0A)
None
None
 1.26A 1l5rA-1tvpA:
undetectable		 1l5rA-1tvpA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		3 / 3 PHE A 245
TRP A 242
GLU A 238
 None
 1.17A 1mogA-1tvpA:
undetectable		 1mogA-1tvpA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 7 PHE A  38
LEU A 258
THR A  40
TYR A  39
 None
 1.10A 1rmtB-1tvpA:
undetectable		 1rmtB-1tvpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 ALA A  90
ILE A  89
VAL A  44
ALA A  47
LEU A  26
 None
 1.23A 1udtA-1tvpA:
undetectable		 1udtA-1tvpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 5 VAL A 226
THR A 225
VAL A 284
GLY A 281
 None
 1.02A 2p2fA-1tvpA:
2.1		 2p2fA-1tvpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 4 VAL A 226
THR A 225
VAL A 284
GLY A 281
 None
 1.00A 2p2fB-1tvpA:
undetectable		 2p2fB-1tvpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 ASN A 134
GLU A 135
HIS A 194
GLU A 222
TRP A 256
 None
EPE  A 700 (-3.4A)
None
EPE  A 700 (-3.5A)
EPE  A 700 (-3.7A)
 0.49A 2v3dA-1tvpA:
17.1		 2v3dA-1tvpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 ALA A  14
TYR A  94
ILE A  12
HIS A 253
 None
 0.84A 2zm8A-1tvpA:
undetectable		 2zm8A-1tvpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 ALA A  14
TYR A  94
ILE A  12
HIS A 253
 None
 0.85A 2zmaA-1tvpA:
undetectable		 2zmaA-1tvpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		3 / 3 HIS A 200
PHE A 245
PHE A 246
 EPE  A 700 (-4.0A)
None
None
 0.36A 3lk0D-1tvpA:
undetectable		 3lk0D-1tvpA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 7 ALA A  58
VAL A 128
VAL A  85
LEU A  81
 None
 0.81A 3o14A-1tvpA:
undetectable		 3o14A-1tvpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 6 HIS A 194
GLU A 222
ASP A  98
SER A  25
 None
EPE  A 700 (-3.5A)
None
None
 1.10A 4apjA-1tvpA:
undetectable
4apjP-1tvpA:
undetectable		 4apjA-1tvpA:
20.47
4apjP-1tvpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 HIS A 253
PHE A 246
GLU A 131
THR A 169
GLY A 168
 None
 1.47A 4hvcA-1tvpA:
undetectable		 4hvcA-1tvpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 9 ILE A 288
ALA A  47
THR A  43
VAL A  84
ALA A  88
 None
 1.30A 4oqrA-1tvpA:
undetectable		 4oqrA-1tvpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 5 ASN A 134
HIS A 100
GLU A 131
THR A 221
 None
 1.40A 4p6sA-1tvpA:
0.3		 4p6sA-1tvpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 THR A 278
GLY A 232
GLY A 233
VAL A 234
 None
 0.76A 4qvvK-1tvpA:
undetectable
4qvvL-1tvpA:
undetectable		 4qvvK-1tvpA:
22.82
4qvvL-1tvpA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 THR A 278
GLY A 232
GLY A 233
VAL A 234
 None
 0.76A 4qvvY-1tvpA:
undetectable
4qvvZ-1tvpA:
undetectable		 4qvvY-1tvpA:
22.82
4qvvZ-1tvpA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 ILE A 132
LEU A 218
LEU A 164
ILE A  12
 None
 0.87A 4r38D-1tvpA:
undetectable		 4r38D-1tvpA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		6 / 12 SER A  25
GLY A 168
SER A 173
GLU A 135
ASN A 134
ALA A 149
 None
None
None
EPE  A 700 (-3.4A)
None
None
 1.45A 4u95B-1tvpA:
undetectable		 4u95B-1tvpA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 GLY A 224
HIS A 253
THR A 225
GLY A 201
PHE A 246
 None
 1.11A 5d4uB-1tvpA:
undetectable		 5d4uB-1tvpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		4 / 7 PHE A 115
THR A 192
ILE A 132
GLY A 168
 None
 0.98A 5nzyA-1tvpA:
2.7		 5nzyA-1tvpA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		3 / 3 THR A 221
GLU A 131
HIS A 100
 None
 0.89A 5xiqB-1tvpA:
undetectable		 5xiqB-1tvpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1tvp CELLULASE
(Pseudoalteromona
s
haloplanktis) 		3 / 3 THR A 221
GLU A 131
HIS A 100
 None
 0.90A 5xiqD-1tvpA:
undetectable		 5xiqD-1tvpA:
19.76