SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.96A 1dvxA-1tvzA:
undetectable		 1dvxA-1tvzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.95A 1dvxB-1tvzA:
undetectable		 1dvxB-1tvzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 6 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.81A 1ictB-1tvzA:
undetectable		 1ictB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		3 / 3 THR A 278
GLU A 109
ASP A 181
 None
 0.85A 1nt2A-1tvzA:
undetectable		 1nt2A-1tvzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 1.02A 1rb3B-1tvzA:
undetectable		 1rb3B-1tvzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 1.07A 1rh3A-1tvzA:
undetectable		 1rh3A-1tvzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 1.05A 1rx3A-1tvzA:
undetectable		 1rx3A-1tvzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 11 LEU A 285
ILE A 118
ALA A 114
THR A 278
MET A  54
 None
 1.39A 2v0mD-1tvzA:
undetectable		 2v0mD-1tvzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		3 / 3 SER A  45
GLY A 154
GLY A 156
 None
 0.56A 3bogA-1tvzA:
undetectable
3bogC-1tvzA:
undetectable		 3bogA-1tvzA:
undetectable
3bogC-1tvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.84A 3cfqA-1tvzA:
undetectable
3cfqB-1tvzA:
undetectable		 3cfqA-1tvzA:
13.66
3cfqB-1tvzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
VAL A 319
 None
 1.22A 3d2tA-1tvzA:
undetectable		 3d2tA-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 6 LYS A   2
ALA A 170
SER A 315
THR A 317
VAL A 319
 None
 1.27A 3d2tB-1tvzA:
undetectable		 3d2tB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 4 PHE A 236
TYR A 277
ILE A 247
LEU A 244
 None
 1.46A 3sudA-1tvzA:
undetectable		 3sudA-1tvzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A 273
GLY A 154
ILE A 136
GLY A 279
ALA A  58
 None
 0.81A 3sufB-1tvzA:
undetectable		 3sufB-1tvzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A 273
GLY A 154
ILE A 136
GLY A 279
ALA A  58
 None
 0.98A 3sufD-1tvzA:
undetectable		 3sufD-1tvzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.80A 4d7bA-1tvzA:
undetectable		 4d7bA-1tvzA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 0.97A 4gh8A-1tvzA:
undetectable		 4gh8A-1tvzA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 8 MET A 107
ALA A 114
LEU A 281
VAL A 135
 None
 0.92A 4iizB-1tvzA:
undetectable		 4iizB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.87A 4ikjA-1tvzA:
undetectable
4ikjB-1tvzA:
undetectable		 4ikjA-1tvzA:
15.95
4ikjB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 8 LYS A   2
ALA A 170
SER A 315
THR A 317
 None
 0.89A 4ikkA-1tvzA:
undetectable
4ikkB-1tvzA:
undetectable		 4ikkA-1tvzA:
15.95
4ikkB-1tvzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		3 / 3 GLY A 308
GLU A 180
THR A 179
 None
 0.54A 4kouA-1tvzA:
undetectable		 4kouA-1tvzA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 8 SER A 229
ALA A 266
SER A 284
TYR A 263
 None
 1.11A 4lv9A-1tvzA:
undetectable
4lv9B-1tvzA:
undetectable		 4lv9A-1tvzA:
22.81
4lv9B-1tvzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 7 TYR A 263
SER A 229
ALA A 266
SER A 284
 None
 1.10A 4lv9A-1tvzA:
undetectable
4lv9B-1tvzA:
undetectable		 4lv9A-1tvzA:
22.81
4lv9B-1tvzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 8 TYR A 282
ILE A 118
LYS A 122
ILE A   5
ALA A 316
 None
 1.32A 4ou1A-1tvzA:
undetectable		 4ou1A-1tvzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 1.09A 4qi9A-1tvzA:
undetectable		 4qi9A-1tvzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 11 ILE A 286
LEU A 281
SER A 229
ILE A 300
LEU A 169
 None
 1.05A 4qleB-1tvzA:
undetectable		 4qleB-1tvzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 5 LEU A 302
TYR A 282
LEU A 285
THR A 115
 None
 1.26A 4wozF-1tvzA:
undetectable
4wozH-1tvzA:
undetectable		 4wozF-1tvzA:
24.75
4wozH-1tvzA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLY A 306
SER A 208
SER A 280
ALA A 113
ALA A 110
 None
 1.34A 4ymgB-1tvzA:
undetectable		 4ymgB-1tvzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		4 / 6 LYS A   2
ALA A 170
SER A 315
VAL A 319
 None
 1.17A 5a6iA-1tvzA:
undetectable		 5a6iA-1tvzA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ALA A 204
THR A 152
GLN A  39
THR A 237
SER A 307
 None
 1.33A 5hfjH-1tvzA:
undetectable		 5hfjH-1tvzA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		3 / 3 TYR A 346
TYR A 193
GLN A 153
 None
 1.15A 5jsdA-1tvzA:
undetectable
5jsdB-1tvzA:
undetectable		 5jsdA-1tvzA:
19.03
5jsdB-1tvzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		3 / 3 TYR A 346
TYR A 193
GLN A 153
 None
 1.17A 5jsdB-1tvzA:
undetectable
5jsdC-1tvzA:
undetectable		 5jsdB-1tvzA:
19.03
5jsdC-1tvzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A 273
ALA A  43
GLY A 154
LEU A 334
LEU A 283
 None
 0.79A 6f6iA-1tvzA:
0.0
6f6iB-1tvzA:
undetectable		 6f6iA-1tvzA:
12.34
6f6iB-1tvzA:
14.12