SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1twb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.13A 1hwiB-1twbA:
undetectable		 1hwiB-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 7 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.05A 1hwiC-1twbA:
0.0		 1hwiC-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 7 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.06A 1hwiD-1twbA:
undetectable		 1hwiD-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.18A 1hwkA-1twbA:
undetectable		 1hwkA-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.15A 1hwkC-1twbA:
undetectable		 1hwkC-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ARG A  74
VAL A  78
SER A  79
ASN A  72
 None
 1.15A 1hwkD-1twbA:
undetectable		 1hwkD-1twbA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.02A 1p6kA-1twbA:
undetectable		 1p6kA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.06A 1p6kB-1twbA:
undetectable		 1p6kB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 6 SER A  55
ALA A  56
SER A  57
THR A  26
 None
 0.79A 1yvpB-1twbA:
undetectable		 1yvpB-1twbA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.02A 1zzqA-1twbA:
undetectable		 1zzqA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.07A 1zzqB-1twbA:
0.0		 1zzqB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.03A 1zzuA-1twbA:
undetectable		 1zzuA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.05A 1zzuB-1twbA:
undetectable		 1zzuB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 7 SER A  55
ALA A  56
SER A  57
THR A  26
 None
 0.82A 2i91A-1twbA:
undetectable		 2i91A-1twbA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 7 SER A  55
ALA A  56
SER A  57
THR A  26
 None
 0.82A 2i91B-1twbA:
undetectable		 2i91B-1twbA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 0.99A 3n62A-1twbA:
undetectable		 3n62A-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.03A 3n62B-1twbA:
undetectable		 3n62B-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.08A 3n66B-1twbA:
undetectable		 3n66B-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 7 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.04A 4kcnB-1twbA:
undetectable		 4kcnB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.02A 5vunA-1twbA:
undetectable		 5vunA-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.08A 5vunB-1twbA:
undetectable		 5vunB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.08A 5vuoB-1twbA:
undetectable		 5vuoB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		4 / 8 ASN A  72
GLN A  63
PHE A  71
ASN A  39
 None
 1.09A 6auuB-1twbA:
undetectable		 6auuB-1twbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1twb STRINGENT STARVATION
PROTEIN B HOMOLOG
(Haemophilus
influenzae) 		5 / 10 GLY A  98
ASN A  97
ILE A  92
ALA A  94
PRO A  27
 None
 1.02A 6e5zA-1twbA:
undetectable		 6e5zA-1twbA:
20.21