SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1twd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 THR A  92
LEU A  43
VAL A  42
ALA A  30
ALA A  29
 None
 1.26A 1q23A-1twdA:
undetectable
1q23B-1twdA:
undetectable		 1q23A-1twdA:
20.00
1q23B-1twdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.78A 1ya3C-1twdA:
undetectable		 1ya3C-1twdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 ALA A 154
GLY A 149
GLY A 157
ALA A 175
PHE A 187
 None
 1.06A 2c49A-1twdA:
undetectable		 2c49A-1twdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 10 TYR A  67
GLY A  62
GLU A  33
GLY A  34
ALA A  30
 None
 1.17A 2ej3B-1twdA:
undetectable		 2ej3B-1twdA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 9 LEU A  95
VAL A 101
THR A 133
VAL A 145
ILE A 142
 None
 1.42A 2l8mA-1twdA:
0.0		 2l8mA-1twdA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 11 PHE A  65
LEU A 134
ILE A 172
ALA A 143
ARG A  59
 None
 1.37A 2v0mA-1twdA:
undetectable		 2v0mA-1twdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		3 / 3 HIS A 121
GLU A  26
HIS A 196
 None
 0.76A 3ba0A-1twdA:
undetectable		 3ba0A-1twdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 8 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.08A 4a97C-1twdA:
undetectable		 4a97C-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 8 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.06A 4a97D-1twdA:
undetectable		 4a97D-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 8 VAL A 118
MET A 106
ILE A 109
GLU A   5
 None
 1.08A 4a97G-1twdA:
undetectable		 4a97G-1twdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.72A 4fn9A-1twdA:
undetectable		 4fn9A-1twdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.67A 4fn9B-1twdA:
undetectable		 4fn9B-1twdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.76A 4ltwA-1twdA:
undetectable		 4ltwA-1twdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		6 / 12 VAL A  91
GLY A  34
GLY A  62
ILE A  57
HIS A 121
LEU A 146
 None
 1.49A 4mwzB-1twdA:
undetectable		 4mwzB-1twdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 VAL A  82
PRO A  56
GLU A   5
HIS A 196
SER A 198
 None
 1.49A 4olfA-1twdA:
undetectable		 4olfA-1twdA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 VAL A  82
PRO A  56
GLU A   5
HIS A 196
SER A 198
 None
 1.39A 4ydqB-1twdA:
undetectable		 4ydqB-1twdA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 10 ALA A 175
GLY A 157
LEU A 158
ALA A 190
ASP A 189
 None
 1.32A 5ajqB-1twdA:
undetectable		 5ajqB-1twdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 9 SER A 198
GLY A 178
ALA A 175
VAL A 179
GLU A   5
 None
 1.46A 5i3cA-1twdA:
undetectable		 5i3cA-1twdA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 7 ARG A  80
THR A  92
ILE A  58
LEU A  90
 None
 0.95A 5te8C-1twdA:
undetectable		 5te8C-1twdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 8 GLY A  93
ARG A 105
ASP A 102
ASP A  64
 None
 0.88A 5vlmB-1twdA:
undetectable		 5vlmB-1twdA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 VAL A  82
PRO A  56
GLU A   5
HIS A 196
SER A 198
 None
 1.48A 5xioA-1twdA:
undetectable		 5xioA-1twdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		5 / 12 VAL A  82
PRO A  56
GLU A   5
HIS A 196
SER A 198
 None
 1.49A 5xiqC-1twdA:
undetectable		 5xiqC-1twdA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1twd COPPER HOMEOSTASIS
PROTEIN CUTC
(Shigella
flexneri) 		4 / 8 LEU A 137
LEU A 134
LEU A 146
GLY A 176
 None
 0.89A 6ce2A-1twdA:
undetectable		 6ce2A-1twdA:
19.33