SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1twl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 130
LEU A 107
PRO A  53
VAL A  54
 None
 1.09A 2dqyC-1twlA:
undetectable		 2dqyC-1twlA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 124
LEU A 130
GLY A  92
ARG A 161
ILE A  91
 None
 1.35A 2ogyB-1twlA:
undetectable		 2ogyB-1twlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 166
TRP A  63
ILE A  59
HIS A   5
 None
 1.03A 2zm8A-1twlA:
undetectable		 2zm8A-1twlA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 166
TRP A  63
ILE A  59
HIS A   5
 None
 1.02A 2zmaA-1twlA:
undetectable		 2zmaA-1twlA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		4 / 8 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 None
 0.73A 3ihzB-1twlA:
undetectable		 3ihzB-1twlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 11 VAL A 106
TRP A 153
ILE A  91
GLY A 155
ALA A 156
 None
 1.16A 3n8yA-1twlA:
undetectable		 3n8yA-1twlA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 106
ILE A 163
GLY A  10
VAL A  74
ILE A  72
 None
 0.98A 3nu6A-1twlA:
undetectable		 3nu6A-1twlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
PRO A  69
GLY A  57
GLU A  22
TYR A  56
 None
 1.10A 5hfjA-1twlA:
undetectable		 5hfjA-1twlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
PRO A  69
GLY A  57
GLU A  22
TYR A  56
 None
 0.99A 5hfjD-1twlA:
undetectable		 5hfjD-1twlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
PRO A  69
GLY A  57
GLU A  22
TYR A  56
 None
 1.04A 5hfjF-1twlA:
undetectable		 5hfjF-1twlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		5 / 8 ILE A 167
VAL A  54
ILE A 133
ASP A  71
PHE A  70
 None
 1.42A 5hi2A-1twlA:
undetectable		 5hi2A-1twlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1twl INORGANIC
PYROPHOSPHATASE
(Pyrococcus
furiosus) 		3 / 3 LEU A  33
ILE A  58
TYR A 170
 None
 0.63A 5uunB-1twlA:
undetectable		 5uunB-1twlA:
22.26