SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1twy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 PHE A 159
VAL A 177
VAL A 147
GLY A 125
TYR A 233
 None
 1.11A 2cbrA-1twyA:
undetectable		 2cbrA-1twyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 SER A  83
ARG A  84
LEU A  86
GLU A  90
 PO4  A1500 (-2.7A)
None
None
None
 0.82A 2cdqB-1twyA:
undetectable		 2cdqB-1twyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 126
LEU A 118
ILE A 131
ILE A 216
VAL A 194
 None
 1.07A 2ygnA-1twyA:
undetectable		 2ygnA-1twyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		3 / 3 SER A 153
GLY A 154
THR A 155
 None
PO4  A1500 ( 3.7A)
None
 0.10A 3k9wA-1twyA:
undetectable		 3k9wA-1twyA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		3 / 3 THR A  82
SER A  83
ARG A  84
 None
PO4  A1500 (-2.7A)
None
 0.65A 3phnA-1twyA:
undetectable		 3phnA-1twyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 5 LYS A 214
VAL A 137
ILE A 216
MET A 190
 None
 1.50A 3pyyB-1twyA:
undetectable		 3pyyB-1twyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 8 GLN A 142
ASN A 197
ASN A 133
THR A 132
 None
 1.36A 4d1yA-1twyA:
undetectable
4d1yB-1twyA:
undetectable		 4d1yA-1twyA:
22.30
4d1yB-1twyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 ALA A  46
ILE A  79
LEU A 259
PHE A 255
 None
 1.03A 4uymB-1twyA:
undetectable		 4uymB-1twyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 11 ALA A  77
THR A  31
ALA A  67
ALA A  80
LEU A 259
 None
 1.13A 5lf7H-1twyA:
undetectable
5lf7I-1twyA:
undetectable		 5lf7H-1twyA:
25.17
5lf7I-1twyA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 VAL A 213
ILE A 107
LEU A 118
VAL A 137
ILE A 126
 None
 1.03A 5mugA-1twyA:
undetectable		 5mugA-1twyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 4 LEU A 240
LEU A 242
SER A  65
ALA A  80
 None
None
PO4  A1500 (-2.7A)
None
 0.99A 5uunA-1twyA:
undetectable		 5uunA-1twyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 11 VAL A 146
THR A 180
VAL A 108
ALA A 178
VAL A 184
 None
 1.35A 6dryA-1twyA:
undetectable		 6dryA-1twyA:
21.03