SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 6 PHE A  45
LEU A 128
VAL A  65
GLN A  44
 None
 1.11A 1e7aB-1tx4A:
0.0		 1e7aB-1tx4A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 8 PRO A  61
GLN A  53
GLU A  60
ARG A 172
 None
 0.91A 3s3mA-1tx4A:
undetectable		 3s3mA-1tx4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 7 PRO A  61
GLN A  53
GLU A  60
ARG A 172
 None
 1.11A 3s3oA-1tx4A:
undetectable		 3s3oA-1tx4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 6 LEU A 171
PHE A 234
LEU A 226
PHE A 222
 None
 1.05A 3wg7C-1tx4A:
undetectable
3wg7J-1tx4A:
undetectable		 3wg7C-1tx4A:
20.82
3wg7J-1tx4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 8 SER A 182
MET A 190
ILE A 181
PHE A 199
 None
 1.26A 4cx7C-1tx4A:
undetectable
4cx7D-1tx4A:
undetectable		 4cx7C-1tx4A:
19.08
4cx7D-1tx4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 233
LEU A 160
LEU A 226
LEU A 171
TYR A 168
 None
 0.95A 4wg0B-1tx4A:
undetectable
4wg0C-1tx4A:
undetectable
4wg0D-1tx4A:
undetectable		 4wg0B-1tx4A:
6.94
4wg0C-1tx4A:
6.94
4wg0D-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 233
LEU A 160
LEU A 226
LEU A 171
TYR A 168
 None
 0.95A 4wg0D-1tx4A:
undetectable
4wg0E-1tx4A:
undetectable
4wg0F-1tx4A:
undetectable		 4wg0D-1tx4A:
6.94
4wg0E-1tx4A:
6.94
4wg0F-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 171
TYR A 168
LEU A 226
LEU A 233
LEU A 160
 None
 0.95A 4wg0C-1tx4A:
undetectable
4wg0D-1tx4A:
undetectable
4wg0E-1tx4A:
undetectable		 4wg0C-1tx4A:
6.94
4wg0D-1tx4A:
6.94
4wg0E-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 233
LEU A 160
LEU A 226
LEU A 171
TYR A 168
 None
 0.93A 4wg0F-1tx4A:
undetectable
4wg0G-1tx4A:
undetectable
4wg0H-1tx4A:
undetectable		 4wg0F-1tx4A:
6.94
4wg0G-1tx4A:
6.94
4wg0H-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 171
TYR A 168
LEU A 226
LEU A 233
LEU A 160
 None
 0.93A 4wg0E-1tx4A:
undetectable
4wg0F-1tx4A:
undetectable
4wg0G-1tx4A:
undetectable		 4wg0E-1tx4A:
6.94
4wg0F-1tx4A:
6.94
4wg0G-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 233
LEU A 160
LEU A 226
LEU A 171
TYR A 168
 None
 0.93A 4wg0H-1tx4A:
undetectable
4wg0I-1tx4A:
undetectable
4wg0J-1tx4A:
undetectable		 4wg0H-1tx4A:
6.94
4wg0I-1tx4A:
6.94
4wg0J-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 171
TYR A 168
LEU A 226
LEU A 233
LEU A 160
 None
 0.96A 4wg0G-1tx4A:
undetectable
4wg0H-1tx4A:
undetectable
4wg0I-1tx4A:
undetectable		 4wg0G-1tx4A:
6.94
4wg0H-1tx4A:
6.94
4wg0I-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 233
LEU A 160
LEU A 226
LEU A 171
TYR A 168
 None
 0.94A 4wg0J-1tx4A:
undetectable
4wg0K-1tx4A:
undetectable
4wg0L-1tx4A:
undetectable		 4wg0J-1tx4A:
6.94
4wg0K-1tx4A:
6.94
4wg0L-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 171
TYR A 168
LEU A 226
LEU A 233
LEU A 160
 None
 0.95A 4wg0I-1tx4A:
undetectable
4wg0J-1tx4A:
undetectable
4wg0K-1tx4A:
undetectable		 4wg0I-1tx4A:
6.94
4wg0J-1tx4A:
6.94
4wg0K-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		5 / 11 LEU A 171
TYR A 168
LEU A 226
LEU A 233
LEU A 160
 None
 0.94A 4wg0K-1tx4A:
undetectable
4wg0L-1tx4A:
undetectable
4wg0M-1tx4A:
undetectable		 4wg0K-1tx4A:
6.94
4wg0L-1tx4A:
6.94
4wg0M-1tx4A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1tx4 P50-RHOGAP
(Homo
sapiens) 		4 / 7 LEU A 226
PHE A 222
ILE A 216
ASN A 202
 None
 1.02A 5n5dA-1tx4A:
undetectable		 5n5dA-1tx4A:
23.64