SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		5 / 9 LEU A 943
ALA A 964
ALA A 948
THR A 951
LEU A 868
 None
 1.03A 1nr6A-1txdA:
undetectable		 1nr6A-1txdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		3 / 3 LEU A 926
PHE A 813
ARG A 923
 None
 0.84A 1xdkB-1txdA:
undetectable		 1xdkB-1txdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		5 / 11 ALA A 884
GLN A 848
LEU A 845
LEU A 880
LEU A 841
 None
 1.11A 2ceoA-1txdA:
undetectable		 2ceoA-1txdA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		4 / 6 MET A 934
LEU A 937
PRO A 941
TYR A 940
 None
 1.21A 3vkxA-1txdA:
0.0		 3vkxA-1txdA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		4 / 5 LEU A 943
HIS A 802
GLU A 799
HIS A 842
 None
 1.36A 4a7bB-1txdA:
undetectable		 4a7bB-1txdA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		4 / 7 PHE A 796
ILE A 792
ASN A 856
ARG A 788
 None
 1.16A 4o7gA-1txdA:
2.3
4o7gB-1txdA:
1.9		 4o7gA-1txdA:
22.57
4o7gB-1txdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		4 / 5 PHE A 796
ARG A 788
ILE A 947
ILE A 792
 None
 1.02A 5dzk4-1txdA:
undetectable
5dzkg-1txdA:
undetectable
5dzkm-1txdA:
undetectable
5dzkn-1txdA:
undetectable		 5dzk4-1txdA:
12.50
5dzkg-1txdA:
20.00
5dzkm-1txdA:
17.88
5dzkn-1txdA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens) 		3 / 3 LYS A 782
PRO A 783
LYS A 787
 None
 1.26A 5y9yA-1txdA:
undetectable		 5y9yA-1txdA:
23.50