SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  76
GLY A  12
VAL A  52
LEU A  50
LEU A  19
 None
 0.79A 1mx1A-1txgA:
undetectable		 1mx1A-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
 None
 0.88A 1mx1C-1txgA:
undetectable		 1mx1C-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  76
GLY A  12
LEU A  50
LEU A  54
LEU A  19
 None
 0.82A 1mx1C-1txgA:
undetectable		 1mx1C-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		6 / 12 LEU A  76
GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
 None
 1.02A 1mx1D-1txgA:
undetectable		 1mx1D-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
 None
 0.93A 1mx1F-1txgA:
undetectable		 1mx1F-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 4 ALA A 141
VAL A 144
ALA A 145
HIS A  47
 None
 1.24A 1q23F-1txgA:
undetectable		 1q23F-1txgA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 306
LEU A 300
ILE A 183
ILE A 232
THR A 308
 None
 1.25A 1rb3A-1txgA:
undetectable		 1rb3A-1txgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 5 LEU A  77
PHE A 169
MET A 165
SER A 161
 None
 1.27A 1wrlC-1txgA:
undetectable		 1wrlC-1txgA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 10 HIS A  47
ALA A 141
ALA A 145
ALA A  14
SER A  13
 None
 1.11A 2r2vC-1txgA:
undetectable
2r2vF-1txgA:
undetectable
2r2vG-1txgA:
undetectable		 2r2vC-1txgA:
8.51
2r2vF-1txgA:
8.51
2r2vG-1txgA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 7 PHE A 174
PHE A 154
ILE A 168
GLY A  12
 None
 0.86A 2v0mC-1txgA:
undetectable		 2v0mC-1txgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 9 ILE A 135
PHE A 174
VAL A 152
GLU A 177
 None
 0.84A 2vufA-1txgA:
undetectable		 2vufA-1txgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 6 THR A 116
GLU A 186
LYS A 192
ILE A 232
 None
None
SO4  A1003 (-2.7A)
None
 1.43A 2w98B-1txgA:
7.0		 2w98B-1txgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 8 LEU A 191
ILE A 187
LEU A 231
THR A 308
LEU A 311
 None
 1.42A 2xfhA-1txgA:
undetectable		 2xfhA-1txgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 102
SER A 104
THR A  81
ALA A 120
 None
 1.02A 3ax9A-1txgA:
undetectable		 3ax9A-1txgA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 SER A  16
ILE A   5
LEU A  76
LEU A  50
LEU A  54
 None
 1.34A 3cs8A-1txgA:
0.0		 3cs8A-1txgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 235
ILE A 182
ILE A 108
ILE A 187
ILE A 183
 None
 0.92A 3ebzA-1txgA:
undetectable		 3ebzA-1txgA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 190
GLY A 184
ILE A 232
VAL A 114
LEU A 107
 None
 1.01A 3ogpA-1txgA:
undetectable		 3ogpA-1txgA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  78
ILE A 135
PRO A 118
VAL A 117
VAL A  84
 None
 1.01A 3ucbB-1txgA:
undetectable		 3ucbB-1txgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 5 THR A  81
ASP A  82
LYS A 292
GLU A 289
 None
 1.31A 3v5vC-1txgA:
0.0
3v5vD-1txgA:
0.0		 3v5vC-1txgA:
23.50
3v5vD-1txgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 8 TRP A  29
THR A  31
LEU A  77
GLY A  83
 None
 0.85A 4c9nA-1txgA:
undetectable		 4c9nA-1txgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 5 LYS A 292
GLU A 289
THR A  81
ASP A  82
 None
 1.33A 4e7cA-1txgA:
0.0
4e7cB-1txgA:
0.0		 4e7cA-1txgA:
23.50
4e7cB-1txgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 103
GLY A   9
GLY A  78
ILE A  28
ILE A  37
 None
 1.03A 4mwzA-1txgA:
5.4		 4mwzA-1txgA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 5 GLY A  83
LEU A 102
ILE A 108
LEU A 124
LEU A  65
 None
 1.35A 4o8fA-1txgA:
undetectable		 4o8fA-1txgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 8 THR A 116
LEU A 235
VAL A 114
SER A 113
 None
 1.07A 4qknA-1txgA:
undetectable		 4qknA-1txgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 204
ILE A 273
SER A 272
GLY A 270
 None
 0.85A 5alcL-1txgA:
undetectable		 5alcL-1txgA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 243
ILE A 225
ASP A 250
 None
None
SO4  A1003 ( 4.3A)
 0.74A 5cswA-1txgA:
undetectable		 5cswA-1txgA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		6 / 12 LEU A 128
ARG A 131
ILE A 100
ILE A  28
ILE A  91
MET A  88
 None
 1.16A 5y2tB-1txgA:
0.0		 5y2tB-1txgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		7 / 12 LEU A 128
ARG A 131
ILE A 100
VAL A  87
ILE A  91
MET A  88
LEU A  19
 None
 1.22A 5ycnA-1txgA:
undetectable		 5ycnA-1txgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		6 / 12 LEU A 128
ARG A 131
ILE A 100
VAL A  87
MET A  88
LEU A  19
 None
 1.18A 5ycnA-1txgA:
undetectable		 5ycnA-1txgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 266
ILE A 273
ILE A 197
VAL A 288
LEU A 280
 None
 1.09A 6ajiA-1txgA:
undetectable		 6ajiA-1txgA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  76
SER A 189
LYS A 105
ASP A 250
VAL A 153
 None
None
SO4  A1003 (-2.7A)
SO4  A1003 ( 4.3A)
None
 1.33A 6bxlA-1txgA:
2.3		 6bxlA-1txgA:
25.06