SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 11 LEU A 312
VAL A 348
VAL A 337
TYR A 366
LEU A 350
 None
 1.42A 1lwcA-1txkA:
undetectable		 1lwcA-1txkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 10 PHE A 310
LEU A 250
GLY A 246
THR A 338
TYR A 383
 None
 1.14A 1rmtA-1txkA:
0.0		 1rmtA-1txkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 7 PHE A 310
LEU A 250
THR A 338
TYR A 383
 None
 1.13A 1rmtB-1txkA:
undetectable		 1rmtB-1txkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 7 ALA A 335
LEU A 312
SER A 274
VAL A 159
 None
 0.98A 1tyrB-1txkA:
undetectable		 1tyrB-1txkA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 10 PHE A 310
LEU A 250
GLY A 246
THR A 338
TYR A 383
 None
 1.16A 2b82A-1txkA:
undetectable		 2b82A-1txkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 9 PHE A 310
LEU A 250
GLY A 246
THR A 338
TYR A 383
 None
 1.14A 2b82B-1txkA:
0.0		 2b82B-1txkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 10 PHE A 310
LEU A 250
GLY A 246
THR A 338
TYR A 383
 None
 1.21A 2b8jB-1txkA:
undetectable		 2b8jB-1txkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 LEU A 136
VAL A 222
ILE A 205
LEU A 203
ILE A 193
 None
 0.85A 2gj5A-1txkA:
undetectable		 2gj5A-1txkA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 10 LEU A 312
VAL A 348
VAL A 337
TYR A 366
LEU A 350
 None
 1.40A 2hndA-1txkA:
0.0		 2hndA-1txkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 6 MET A 488
ILE A 425
ARG A 407
SER A 300
 None
 1.06A 2qd3B-1txkA:
undetectable		 2qd3B-1txkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 9 TYR A 218
PRO A 373
LEU A 372
LEU A 238
ALA A 214
 None
 1.14A 2vcvE-1txkA:
undetectable		 2vcvE-1txkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 7 PRO A 186
ALA A 214
LEU A 209
PHE A 381
 None
 1.00A 2vcvL-1txkA:
undetectable		 2vcvL-1txkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 PHE A 188
ILE A 236
PHE A 310
ALA A 170
TYR A 383
 None
 1.14A 3apwA-1txkA:
undetectable		 3apwA-1txkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ALA A 214
GLY A  37
VAL A 242
VAL A 247
LEU A 173
 None
 1.06A 3m6wA-1txkA:
undetectable		 3m6wA-1txkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 LEU A 312
VAL A 348
VAL A 337
TYR A 366
LEU A 350
 None
 1.36A 3medA-1txkA:
undetectable
3medB-1txkA:
undetectable		 3medA-1txkA:
22.76
3medB-1txkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ILE A 385
LEU A 250
GLY A 161
VAL A 159
LEU A 168
 None
 1.02A 3uq6A-1txkA:
undetectable		 3uq6A-1txkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ILE A 385
LEU A 250
GLY A 161
VAL A 159
LEU A 168
 None
 1.02A 3vaqA-1txkA:
undetectable		 3vaqA-1txkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ILE A 385
LEU A 250
GLY A 161
VAL A 159
LEU A 168
 None
 1.01A 3vasA-1txkA:
undetectable		 3vasA-1txkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ALA A 491
THR A 449
ALA A 400
ASP A 398
GLN A 497
 None
 1.49A 4df3A-1txkA:
undetectable		 4df3A-1txkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 8 SER A 300
GLU A 352
PHE A 427
VAL A 477
 None
 0.94A 4dx7B-1txkA:
undetectable		 4dx7B-1txkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 6 PRO A 508
ILE A 425
TYR A 505
PHE A 427
 None
 1.23A 4g10A-1txkA:
undetectable		 4g10A-1txkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 7 ALA A 214
PRO A 212
LEU A 209
TYR A 218
 None
 0.99A 4iomA-1txkA:
undetectable		 4iomA-1txkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 8 ALA A 214
PRO A 212
LEU A 209
TYR A 218
LEU A 173
 None
 1.38A 4jjkA-1txkA:
undetectable		 4jjkA-1txkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 6 PHE A 427
MET A 488
ILE A 425
ARG A 407
 None
 1.09A 4mk4B-1txkA:
undetectable		 4mk4B-1txkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 PHE A 220
LEU A 203
VAL A 149
GLY A 153
PHE A 133
 None
 1.34A 4mubA-1txkA:
undetectable		 4mubA-1txkA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 8 LEU A 312
VAL A 348
VAL A 337
TYR A 366
LEU A 350
 None
 1.46A 4puoC-1txkA:
undetectable		 4puoC-1txkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 VAL A 474
GLU A 459
ALA A 426
THR A 486
ARG A 489
 None
 1.40A 5hnzB-1txkA:
undetectable		 5hnzB-1txkA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 PRO A 290
GLU A 456
VAL A 429
GLY A 410
THR A 424
 None
 0.90A 5igpA-1txkA:
0.7		 5igpA-1txkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 PRO A 290
GLU A 456
VAL A 429
GLY A 410
THR A 424
 None
 0.90A 5igtA-1txkA:
0.7		 5igtA-1txkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		3 / 3 TYR A  40
TYR A 218
SER A 155
 None
 0.90A 5iktB-1txkA:
undetectable		 5iktB-1txkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		5 / 12 ILE A 193
PHE A 130
VAL A  93
PHE A  82
VAL A 135
 None
 1.28A 5n0xB-1txkA:
undetectable		 5n0xB-1txkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 8 ILE A 205
LEU A 203
ILE A 193
ILE A  95
 None
 0.73A 5numA-1txkA:
undetectable		 5numA-1txkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 7 ARG A 213
ALA A 174
ILE A 236
LEU A 209
 None
 0.93A 5te8C-1txkA:
undetectable		 5te8C-1txkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		4 / 8 THR A 405
PHE A 254
VAL A 402
PRO A 290
 None
 1.14A 5vkqB-1txkA:
undetectable
5vkqC-1txkA:
undetectable		 5vkqB-1txkA:
13.77
5vkqC-1txkA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1txk GLUCANS BIOSYNTHESIS
PROTEIN G
(Escherichia
coli) 		3 / 3 ASN A  65
VAL A 118
HIS A 120
 None
 0.81A 6a5yD-1txkA:
undetectable		 6a5yD-1txkA:
9.96