SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 113
ARG A 110
PHE A 106
GLY A 108
 None
 0.89A 1fapB-1txoA:
0.0		 1fapB-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 117
ASP A 135
GLY A 121
THR A 176
 None
 1.02A 1hxbB-1txoA:
undetectable		 1hxbB-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 117
VAL A  77
SER A  50
LEU A 166
LEU A  57
 None
 1.01A 1ya4B-1txoA:
undetectable		 1ya4B-1txoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 117
VAL A  77
SER A  50
LEU A 166
LEU A  57
 None
 1.02A 1ya4C-1txoA:
undetectable		 1ya4C-1txoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  57
VAL A  53
GLY A  80
VAL A 171
ILE A 116
 None
 1.29A 2a1oB-1txoA:
undetectable		 2a1oB-1txoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 180
ARG A 181
LEU A   6
ASP A 126
 None
 1.05A 2bxkA-1txoA:
undetectable		 2bxkA-1txoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 LEU A   8
VAL A 234
ALA A 236
TYR A 186
LEU A 111
 None
 1.23A 2japA-1txoA:
undetectable		 2japA-1txoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 LEU A   8
VAL A 234
ALA A 236
TYR A 186
LEU A 111
 None
 1.25A 2japC-1txoA:
undetectable		 2japC-1txoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 5 LEU A   6
VAL A  27
LEU A  36
ARG A  13
 None
 0.87A 2oiqA-1txoA:
undetectable		 2oiqA-1txoA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 116
LEU A 101
VAL A  53
GLY A  80
ARG A  78
 None
 1.28A 2wd9C-1txoA:
undetectable		 2wd9C-1txoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  57
ALA A  37
ASP A  38
ASP A  25
ILE A  84
ILE A  54
 None
None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.8A)
None
None
 1.33A 3bvbB-1txoA:
undetectable		 3bvbB-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		6 / 10 LEU A  57
ALA A  37
ASP A  38
ASP A  25
ILE A  84
ILE A  54
 None
None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.8A)
None
None
 1.39A 3ekvA-1txoA:
undetectable		 3ekvA-1txoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 196
VAL A 197
THR A 133
GLY A 121
 None
 1.01A 3elzB-1txoA:
1.7		 3elzB-1txoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 8 ALA A  37
ASP A  25
ASP A  38
LEU A  34
VAL A 114
 None
MN  A 700 ( 4.8A)
MN  A 700 ( 2.6A)
None
None
 1.48A 3em6A-1txoA:
undetectable		 3em6A-1txoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 117
ASP A 135
GLY A 121
THR A 176
 None
 1.07A 3k4vC-1txoA:
undetectable		 3k4vC-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  53
VAL A 114
LEU A 175
ALA A  76
LEU A  57
 None
 1.04A 3n8wA-1txoA:
undetectable		 3n8wA-1txoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  53
VAL A 114
LEU A 175
ALA A  76
LEU A  57
 None
 1.04A 3n8zA-1txoA:
undetectable		 3n8zA-1txoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 118
GLY A 192
GLN A 158
ARG A  20
 MN  A 702 (-2.7A)
MN  A 700 ( 4.9A)
None
None
 0.91A 3s3nA-1txoA:
undetectable		 3s3nA-1txoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		5 / 11 THR A 102
THR A 130
SER A 194
LEU A 188
VAL A 235
 None
 1.42A 3tbgA-1txoA:
undetectable		 3tbgA-1txoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  57
ALA A  37
ASP A  38
ASP A  25
ILE A  84
ILE A  54
 None
None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.8A)
None
None
 1.28A 4jecA-1txoA:
undetectable		 4jecA-1txoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 197
SER A 198
THR A 201
 None
 0.33A 4luhA-1txoA:
undetectable		 4luhA-1txoA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  20
ASP A  38
GLY A  39
ASP A  25
 None
MN  A 700 ( 2.6A)
MN  A 701 (-4.2A)
MN  A 700 ( 4.8A)
 1.30A 5hp1A-1txoA:
undetectable		 5hp1A-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  20
ASP A 191
GLY A 192
ASP A 195
 None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.9A)
MN  A 702 ( 4.1A)
 1.17A 5hp1A-1txoA:
undetectable		 5hp1A-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  20
ASP A  38
GLY A  39
ASP A  25
 None
MN  A 700 ( 2.6A)
MN  A 701 (-4.2A)
MN  A 700 ( 4.8A)
 1.22A 5hp1C-1txoA:
0.0		 5hp1C-1txoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  57
ALA A  37
ASP A  38
ASP A  25
ILE A  84
ILE A  54
 None
None
MN  A 700 ( 2.6A)
MN  A 700 ( 4.8A)
None
None
 1.34A 5t2zB-1txoA:
undetectable		 5t2zB-1txoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1txo PUTATIVE BACTERIAL
ENZYME
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 175
ASN A  81
LEU A  57
 None
 0.69A 6exiA-1txoA:
undetectable		 6exiA-1txoA:
21.34