SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		3 / 3 ASP A 279
PHE A 224
ARG A 330
 ASP  A 279 ( 0.6A)
PHE  A 224 ( 1.3A)
ARG  A 330 ( 0.6A)
 0.82A 2a3aA-1txuA:
undetectable		 2a3aA-1txuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		3 / 3 ASP A 260
ASN A 258
THR A 318
 ASP  A 260 ( 0.5A)
ASN  A 258 ( 0.6A)
THR  A 318 ( 0.8A)
 0.70A 2pymB-1txuA:
undetectable		 2pymB-1txuA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		3 / 3 ASP A 260
ASN A 258
THR A 318
 ASP  A 260 ( 0.5A)
ASN  A 258 ( 0.6A)
THR  A 318 ( 0.8A)
 0.70A 2q63B-1txuA:
undetectable		 2q63B-1txuA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		5 / 11 ILE A 175
SER A 174
PHE A 341
ALA A 182
GLU A 180
 ILE  A 175 ( 0.3A)
SER  A 174 ( 0.0A)
PHE  A 341 ( 1.3A)
ALA  A 182 ( 0.0A)
GLU  A 180 ( 0.5A)
 0.95A 3kw4A-1txuA:
undetectable		 3kw4A-1txuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		4 / 5 LEU A 146
GLY A 153
ILE A 211
GLN A 210
 LEU  A 146 ( 0.6A)
GLY  A 153 ( 0.0A)
ILE  A 211 ( 0.7A)
GLN  A 210 ( 0.6A)
 1.08A 4ma8C-1txuA:
2.1		 4ma8C-1txuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		4 / 8 GLU A 232
GLN A 239
ILE A 242
LEU A 331
 GLU  A 232 ( 0.5A)
GLN  A 239 ( 0.6A)
ILE  A 242 ( 0.7A)
LEU  A 331 ( 0.6A)
 0.76A 4mj8A-1txuA:
undetectable		 4mj8A-1txuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		4 / 7 PHE A 145
PHE A 142
LYS A 213
TYR A 214
 PHE  A 145 ( 1.3A)
PHE  A 142 ( 1.3A)
LYS  A 213 ( 0.0A)
TYR  A 214 ( 1.3A)
 1.42A 4uciB-1txuA:
0.0		 4uciB-1txuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		5 / 12 PRO A 329
ASP A 235
LYS A 234
ILE A 238
ASP A 230
 PRO  A 329 ( 1.1A)
ASP  A 235 ( 0.5A)
LYS  A 234 ( 0.0A)
ILE  A 238 ( 0.4A)
ASP  A 230 ( 0.6A)
 0.94A 5wwsB-1txuA:
undetectable		 5wwsB-1txuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1txu RAB5 GDP/GTP
EXCHANGE FACTOR
(Homo
sapiens) 		5 / 9 ILE A 242
ALA A 244
MET A 385
LEU A 369
PRO A 317
 ILE  A 242 ( 0.7A)
ALA  A 244 ( 0.0A)
TRP  A 247 ( 3.6A)
LEU  A 369 ( 0.6A)
PRO  A 317 ( 1.1A)
 1.36A 5z6lA-1txuA:
undetectable		 5z6lA-1txuA:
20.74