SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1txz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 THR A 148
ALA A 198
GLY A 118
ALA A 173
SER A  81
 APR  A 285 (-2.8A)
APR  A 285 (-3.4A)
None
None
None
 1.20A 2f162-1txzA:
undetectable		 2f162-1txzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 THR A 148
ALA A 198
GLY A 118
ALA A 173
SER A  81
 APR  A 285 (-2.8A)
APR  A 285 (-3.4A)
None
None
None
 1.20A 2f16N-1txzA:
undetectable		 2f16N-1txzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  79
PHE A 106
ILE A 143
PHE A 102
 APR  A 285 (-3.6A)
None
None
None
 0.94A 2qmzA-1txzA:
undetectable
2qmzB-1txzA:
undetectable		 2qmzA-1txzA:
21.00
2qmzB-1txzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 188
ALA A 120
MET A 179
PHE A 171
LEU A 235
 None
 1.32A 3b0wB-1txzA:
undetectable		 3b0wB-1txzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 THR A 148
ALA A 198
SER A 119
GLY A 118
ALA A 173
 APR  A 285 (-2.8A)
APR  A 285 (-3.4A)
None
None
None
 1.07A 3mg02-1txzA:
undetectable
3mg0V-1txzA:
undetectable		 3mg02-1txzA:
22.15
3mg0V-1txzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 10 THR A  29
PRO A 191
ASN A  25
GLY A 196
GLY A  52
 None
APR  A 285 ( 4.9A)
None
APR  A 285 (-3.2A)
SO4  A 288 ( 3.4A)
 1.21A 3pp7B-1txzA:
undetectable		 3pp7B-1txzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 264
LYS A 207
SER A 208
 None
 1.26A 3tyeB-1txzA:
undetectable		 3tyeB-1txzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  86
GLY A  87
TYR A 197
GLU A 103
 EDO  A 286 (-3.7A)
APR  A 285 (-3.3A)
APR  A 285 (-4.0A)
None
 0.86A 4fgkB-1txzA:
undetectable		 4fgkB-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 189
VAL A 146
PHE A 106
ILE A 143
PHE A 102
 None
 0.88A 4fglA-1txzA:
undetectable
4fglB-1txzA:
undetectable		 4fglA-1txzA:
21.33
4fglB-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  79
PHE A 106
ILE A 143
PHE A 102
 APR  A 285 (-3.6A)
None
None
None
 0.79A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 146
PHE A 106
ILE A 143
PHE A 102
 None
 0.76A 4fglC-1txzA:
undetectable		 4fglC-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 8 PRO A  78
VAL A 146
ASN A 176
ILE A 190
 NA  A 289 ( 4.0A)
None
SO4  A 287 (-3.8A)
None
 0.96A 4iilA-1txzA:
undetectable		 4iilA-1txzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 189
GLY A  79
PHE A 106
ILE A 143
PHE A 102
 None
APR  A 285 (-3.6A)
None
None
None
 1.01A 4qoiA-1txzA:
undetectable
4qoiB-1txzA:
undetectable		 4qoiA-1txzA:
21.33
4qoiB-1txzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 8 THR A 195
LEU A  31
LEU A  21
PHE A  89
 APR  A 285 (-3.6A)
None
None
APR  A 285 ( 4.9A)
 0.98A 4r38B-1txzA:
undetectable		 4r38B-1txzA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 240
TYR A 233
LEU A 261
PHE A 243
 None
 1.33A 4twdF-1txzA:
undetectable
4twdG-1txzA:
undetectable		 4twdF-1txzA:
19.37
4twdG-1txzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 120
GLY A 118
LEU A 213
LEU A 188
LEU A 178
 None
 1.16A 4zmeA-1txzA:
undetectable		 4zmeA-1txzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 120
GLY A 118
VAL A  76
LEU A 188
LEU A 178
 None
 1.12A 4zmeA-1txzA:
undetectable		 4zmeA-1txzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 226
ILE A 222
PRO A 276
LEU A 274
 None
 1.09A 5eb3A-1txzA:
undetectable		 5eb3A-1txzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  19
ILE A 185
MET A 217
 None
 0.71A 5i9yA-1txzA:
undetectable		 5i9yA-1txzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 271
ILE A 275
ILE A 231
ALA A 212
LEU A 215
 None
 1.00A 5mvmA-1txzA:
undetectable
5mvmE-1txzA:
undetectable		 5mvmA-1txzA:
14.59
5mvmE-1txzA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 231
ALA A 212
LEU A 215
ILE A 271
ILE A 275
 None
 1.02A 5mvmD-1txzA:
undetectable
5mvmE-1txzA:
undetectable		 5mvmD-1txzA:
14.59
5mvmE-1txzA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  96
GLN A  55
GLY A 187
ILE A 140
 None
APR  A 285 (-3.5A)
None
None
 1.08A 6debB-1txzA:
undetectable		 6debB-1txzA:
14.91