SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ty2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.90A 1p7lD-1ty2A:
undetectable		 1p7lD-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.89A 1p7lC-1ty2A:
undetectable		 1p7lC-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.92A 1rg9B-1ty2A:
undetectable		 1rg9B-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.89A 1rg9A-1ty2A:
undetectable		 1rg9A-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.89A 1rg9D-1ty2A:
undetectable		 1rg9D-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.89A 1rg9C-1ty2A:
undetectable		 1rg9C-1ty2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 ASP A 135
ILE A 138
LEU A 142
TYR A 175
 None
 1.04A 2ya7A-1ty2A:
undetectable		 2ya7A-1ty2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 ASP A 135
ILE A 138
LEU A 142
TYR A 175
 None
 1.01A 2ya7B-1ty2A:
undetectable		 2ya7B-1ty2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 ASP A 135
ILE A 138
LEU A 142
TYR A 175
 None
 1.03A 2ya7D-1ty2A:
undetectable		 2ya7D-1ty2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 LEU A  33
ILE A  30
ILE A 128
PHE A  64
VAL A  56
 None
 1.07A 2ygoA-1ty2A:
undetectable		 2ygoA-1ty2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		6 / 12 LEU A  33
ILE A  30
ILE A 128
PRO A 127
PHE A  64
VAL A  56
 None
 1.37A 2ygqA-1ty2A:
undetectable		 2ygqA-1ty2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 ILE A  87
THR A  80
PHE A  50
TYR A  85
 None
 1.25A 3elzB-1ty2A:
0.0		 3elzB-1ty2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 7 GLY A 106
ILE A 162
LEU A 160
PHE A 134
 None
 0.88A 4ejjD-1ty2A:
undetectable		 4ejjD-1ty2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 7 GLY A 106
PHE A 201
ILE A 162
PHE A 129
 None
 0.87A 4fglC-1ty2A:
undetectable		 4fglC-1ty2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4jksA-1ty2A:
undetectable		 4jksA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4jksB-1ty2A:
undetectable		 4jksB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.97A 4jkuA-1ty2A:
undetectable		 4jkuA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.97A 4k8cA-1ty2A:
undetectable		 4k8cA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.96A 4k8cB-1ty2A:
undetectable		 4k8cB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4k8kA-1ty2A:
undetectable		 4k8kA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4k8kB-1ty2A:
undetectable		 4k8kB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4kahA-1ty2A:
undetectable		 4kahA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4kahB-1ty2A:
undetectable		 4kahB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.97A 4kalA-1ty2A:
undetectable		 4kalA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4kalB-1ty2A:
undetectable		 4kalB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.99A 4kanA-1ty2A:
undetectable		 4kanA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4kanB-1ty2A:
undetectable		 4kanB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.99A 4kbeA-1ty2A:
undetectable		 4kbeA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4kbeB-1ty2A:
undetectable		 4kbeB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.77A 4kttB-1ty2A:
undetectable		 4kttB-1ty2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4lbgA-1ty2A:
undetectable		 4lbgA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4lbgB-1ty2A:
undetectable		 4lbgB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.98A 4lcaA-1ty2A:
undetectable		 4lcaA-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 ILE A  87
GLY A  90
GLY A  89
ASN A 193
ILE A  40
 None
 0.97A 4lcaB-1ty2A:
undetectable		 4lcaB-1ty2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLU A 170
ASP A 205
ASP A 135
ILE A 138
 None
ZN  A 700 (-2.3A)
None
None
 0.79A 4ndnB-1ty2A:
undetectable		 4ndnB-1ty2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ty2 PUTATIVE EXOTOXIN
(SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 GLY A 106
PHE A 201
ILE A 162
PHE A 129
 None
 0.91A 4qogA-1ty2A:
0.0
4qogB-1ty2A:
0.0		 4qogA-1ty2A:
22.03
4qogB-1ty2A:
22.03