SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ty4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 12 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.08A 1bsxA-1ty4A:
undetectable		 1bsxA-1ty4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 12 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.07A 1bsxB-1ty4A:
undetectable		 1bsxB-1ty4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 12 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.07A 2h77A-1ty4A:
undetectable		 2h77A-1ty4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		3 / 3 MET C  61
MET A 119
PHE A 177
 None
 1.26A 3gn8A-1ty4C:
undetectable		 3gn8A-1ty4C:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 12 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.08A 3gwsX-1ty4A:
undetectable		 3gwsX-1ty4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 10 SER A 147
LEU C  58
ILE C  54
SER C  48
GLY C  51
 None
 1.33A 3iluB-1ty4A:
undetectable
3iluE-1ty4A:
undetectable		 3iluB-1ty4A:
20.22
3iluE-1ty4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 11 ILE C  54
SER C  48
GLY C  51
SER A 147
LEU C  58
 None
 1.31A 3iluB-1ty4C:
undetectable
3iluE-1ty4C:
undetectable		 3iluB-1ty4C:
13.78
3iluE-1ty4C:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1ty4 APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 11 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.38A 3v3nA-1ty4A:
undetectable		 3v3nA-1ty4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1ty4 APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 11 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.38A 3v3nD-1ty4A:
0.0		 3v3nD-1ty4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		3 / 3 MET A 119
MET C  61
TYR A 168
 None
 1.23A 4p6xI-1ty4A:
undetectable		 4p6xI-1ty4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR
(Caenorhabditis
elegans) 		5 / 12 ILE A 172
ARG A 219
MET A 231
MET C  69
ALA C  67
 None
 1.15A 4zo1X-1ty4A:
undetectable		 4zo1X-1ty4A:
22.78