SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP E  97
GLY E  77
ASN E  89
PRO E  79
 None
 1.21A 1dedA-1tydE:
undetectable		 1dedA-1tydE:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 9 PHE E 231
THR E 258
LEU E 298
VAL E 302
ILE E  46
 None
 1.28A 1gebA-1tydE:
undetectable		 1gebA-1tydE:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLY E  36
HIS E  45
HIS E  48
GLY E 192
ASP E 194
 TYR  E 320 (-3.3A)
None
None
None
None
 0.83A 1jzsA-1tydE:
undetectable		 1jzsA-1tydE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		6 / 11 GLY E  36
HIS E  48
GLY E 192
ASP E 194
GLN E 195
LEU E 222
 TYR  E 320 (-3.3A)
None
None
None
TYR  E 320 (-3.3A)
None
 0.73A 1jzsA-1tydE:
undetectable		 1jzsA-1tydE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE E  66
HIS E  48
LEU E 105
ASN E 198
ASP E 194
 None
 1.42A 1mrlA-1tydE:
0.0
1mrlB-1tydE:
0.0		 1mrlA-1tydE:
18.90
1mrlB-1tydE:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU E  44
GLY E  71
GLY E  74
ILE E 101
LEU E 109
 None
 1.09A 1p91B-1tydE:
2.4		 1p91B-1tydE:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS E  45
GLY E  47
HIS E  48
GLY E 192
ASP E 194
 None
 0.54A 1pg2A-1tydE:
9.2		 1pg2A-1tydE:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY E  47
HIS E  48
GLY E 192
ASP E 194
GLN E 195
 None
None
None
None
TYR  E 320 (-3.3A)
 0.70A 1qu2A-1tydE:
4.0		 1qu2A-1tydE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS E  48
GLY E 192
ASP E 194
GLN E 195
VAL E 223
 None
None
None
TYR  E 320 (-3.3A)
None
 0.73A 1qu2A-1tydE:
4.0		 1qu2A-1tydE:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 7 PHE E 231
THR E 258
LEU E 298
VAL E 302
ILE E  46
 None
 1.33A 1t87B-1tydE:
undetectable		 1t87B-1tydE:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASP E  38
GLY E  70
GLY E  71
ASN E 123
 TYR  E 320 (-3.6A)
TYR  E 320 ( 4.9A)
None
TYR  E 320 ( 4.7A)
 0.74A 2c49B-1tydE:
undetectable		 2c49B-1tydE:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS E  45
GLY E  47
HIS E  48
GLY E 192
ASP E 194
 None
 0.64A 2x1lA-1tydE:
9.2		 2x1lA-1tydE:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS E  45
GLY E  47
HIS E  48
GLY E 192
ASP E 194
 None
 0.65A 2x1lB-1tydE:
9.4		 2x1lB-1tydE:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS E  45
GLY E  47
HIS E  48
GLY E 192
ASP E 194
 None
 0.70A 2x1lC-1tydE:
9.4		 2x1lC-1tydE:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER E  43
ILE E 120
ALA E 118
PHE E 108
LEU E 305
 None
 1.29A 3vw1B-1tydE:
0.0		 3vw1B-1tydE:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN E 123
TRP E 126
ASP E  38
 TYR  E 320 ( 4.7A)
None
TYR  E 320 (-3.6A)
 0.85A 4a7tA-1tydE:
undetectable
4a7tF-1tydE:
undetectable		 4a7tA-1tydE:
17.61
4a7tF-1tydE:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR E 258
LEU E 298
VAL E 302
ILE E  46
 None
 0.99A 4l4cB-1tydE:
undetectable		 4l4cB-1tydE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU E 172
GLY E 197
ASP E 176
VAL E 139
PHE E 143
 None
None
TYR  E 320 (-3.5A)
None
None
 1.21A 4wnwA-1tydE:
undetectable		 4wnwA-1tydE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG E 107
PHE E 270
LEU E 241
 None
 0.93A 5x1bC-1tydE:
undetectable		 5x1bC-1tydE:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tyd TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE E  46
PHE E 254
TYR E 266
THR E 224
 None
 1.24A 5z84N-1tydE:
0.0
5z84W-1tydE:
undetectable		 5z84N-1tydE:
18.76
5z84W-1tydE:
10.77