SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 GLY B 154
ALA B 155
GLY B 221
GLY B 222
ILE B 226
 None
 0.84A 1hxbA-1tyeB:
undetectable		 1hxbA-1tyeB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 8 THR B   7
LEU B  40
ASP B  39
GLU B  42
 None
 1.05A 1mxgA-1tyeB:
undetectable		 1mxgA-1tyeB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 VAL B 359
ILE B 416
ILE B 399
PHE B 100
PHE B 370
 None
 0.89A 1qhsA-1tyeB:
2.2		 1qhsA-1tyeB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 GLY B 222
ASN B 215
ASP B 224
ALA B 225
ALA B 229
 None
CA  B1403 ( 2.7A)
None
None
None
 0.81A 2br4B-1tyeB:
undetectable		 2br4B-1tyeB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 GLY B 154
ALA B 155
GLY B 221
GLY B 222
ILE B 226
 None
 0.86A 2fxeA-1tyeB:
undetectable		 2fxeA-1tyeB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		3 / 3 SER B 282
TYR B 281
HIS B 280
 None
 0.63A 2r2vD-1tyeB:
undetectable		 2r2vD-1tyeB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		8 / 12 SER B 121
TYR B 122
SER B 123
TYR B 166
ARG B 214
ASN B 215
ALA B 218
GLU B 220
 MG  B1401 ( 2.1A)
None
MG  B1401 (-2.1A)
None
None
CA  B1403 ( 2.7A)
None
CAC  B1301 (-2.9A)
 0.54A 2vdmA-1tyeB:
0.0
2vdmB-1tyeB:
46.4		 2vdmA-1tyeB:
22.96
2vdmB-1tyeB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 TYR B 289
HIS B 255
ASP B 217
ASP B 158
ILE B 265
 None
None
CA  B1403 ( 2.8A)
CA  B1403 (-3.0A)
None
 1.30A 3b7pA-1tyeB:
undetectable		 3b7pA-1tyeB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 TYR B 289
HIS B 255
ASP B 217
ASP B 158
ILE B 265
 None
None
CA  B1403 ( 2.8A)
CA  B1403 (-3.0A)
None
 1.37A 3b7pB-1tyeB:
undetectable		 3b7pB-1tyeB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 TYR B 289
HIS B 255
ASP B 217
ASP B 158
ILE B 265
 None
None
CA  B1403 ( 2.8A)
CA  B1403 (-3.0A)
None
 1.32A 3b7pC-1tyeB:
undetectable		 3b7pC-1tyeB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 ALA B 263
TYR B 281
ASP B 224
GLY B 264
ILE B 265
 None
 1.30A 3vwqA-1tyeB:
undetectable		 3vwqA-1tyeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 8 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.80A 4fglD-1tyeB:
3.2		 4fglD-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 7 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.74A 4fglC-1tyeB:
4.8		 4fglC-1tyeB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 8 LEU B 368
VAL B 359
LEU B  92
LEU B  90
 None
 0.67A 4l1xA-1tyeB:
undetectable		 4l1xA-1tyeB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 LEU B 246
LEU B 306
MET B 295
PHE B 308
LEU B 117
 None
 1.00A 4lmnA-1tyeB:
undetectable		 4lmnA-1tyeB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 ASN B 269
ALA B 225
GLY B 222
GLY B 221
GLY B 154
 None
 0.98A 4obwB-1tyeB:
2.3		 4obwB-1tyeB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 6 GLY B 221
PHE B 248
ILE B 226
PHE B 308
 None
 0.83A 4qogA-1tyeB:
5.0
4qogB-1tyeB:
5.0		 4qogA-1tyeB:
19.25
4qogB-1tyeB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		5 / 12 PHE B 100
ILE B 416
LEU B 362
LEU B  92
LEU B  90
 None
 1.33A 4qynB-1tyeB:
undetectable		 4qynB-1tyeB:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		3 / 3 GLY B 271
GLN B 228
LYS B 298
 None
 0.88A 5imsB-1tyeB:
2.2		 5imsB-1tyeB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		4 / 4 GLU B  65
PRO B  85
ILE B  88
LEU B  64
 None
 1.31A 5m45J-1tyeB:
0.0		 5m45J-1tyeB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		3 / 3 GLY B 237
ASP B 113
ILE B 151
 None
 0.54A 6dgxB-1tyeB:
undetectable		 6dgxB-1tyeB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1tye INTEGRIN BETA-3
(Homo
sapiens) 		3 / 3 TYR B 190
ASP B 224
GLN B 228
 None
 0.96A 6g1pA-1tyeB:
undetectable		 6g1pA-1tyeB:
21.59