SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 12 ASP A 314
GLY A 261
SER A 260
ALA A 313
ALA A 309
 None
 1.32A 1nw5A-1tygA:
undetectable		 1nw5A-1tygA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 7 ALA A 285
ILE A 287
ASP A 284
ILE A 264
 PO4  A1400 (-3.8A)
None
None
None
 0.97A 1yc5A-1tygA:
undetectable		 1yc5A-1tygA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
YJBS
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 GLY A 118
PHE B  62
GLY B  64
GLY A 120
PRO A 170
 None
 1.10A 2dpmA-1tygA:
undetectable		 2dpmA-1tygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1tyg YJBS
(Bacillus
subtilis) 		4 / 8 LEU B   2
ASP B  55
ILE B  41
LEU B   4
 None
 0.72A 2o4nB-1tygB:
undetectable		 2o4nB-1tygB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 12 ARG A 183
ILE A 197
LEU A 222
GLY A 226
ALA A 185
 None
 0.87A 2oc8A-1tygA:
undetectable		 2oc8A-1tygA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 8 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.89A 3asoC-1tygA:
undetectable
3asoJ-1tygA:
undetectable		 3asoC-1tygA:
21.65
3asoJ-1tygA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 12 LEU A 299
ALA A 255
ASP A 284
VAL A 304
GLY A 288
 None
 0.93A 3so9B-1tygA:
undetectable		 3so9B-1tygA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 10 ILE A 184
ALA A 181
VAL A 229
MET A 252
LEU A 169
 None
 1.39A 4kq8A-1tygA:
0.0		 4kq8A-1tygA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 12 VAL A 132
ALA A 133
PHE A 142
PHE A 157
THR A 119
 None
 1.34A 4mm4A-1tygA:
undetectable		 4mm4A-1tygA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 7 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.91A 5b1aC-1tygA:
undetectable
5b1aJ-1tygA:
undetectable		 5b1aC-1tygA:
21.65
5b1aJ-1tygA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 7 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.90A 5b1aP-1tygA:
undetectable
5b1aW-1tygA:
undetectable		 5b1aP-1tygA:
21.65
5b1aW-1tygA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 7 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.90A 5b3sC-1tygA:
undetectable
5b3sJ-1tygA:
undetectable		 5b3sC-1tygA:
21.65
5b3sJ-1tygA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		4 / 7 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.90A 5b3sP-1tygA:
undetectable		 5b3sP-1tygA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 12 LEU A 270
GLY A 254
GLU A 244
LEU A 243
LEU A 239
 None
 1.26A 5nwvA-1tygA:
undetectable		 5nwvA-1tygA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Bacillus
subtilis) 		5 / 10 LEU A 230
PRO A 231
MET A 252
LEU A 243
THR A 215
 None
 1.29A 6hupD-1tygA:
undetectable
6hupE-1tygA:
undetectable		 6hupD-1tygA:
15.81
6hupE-1tygA:
13.90