SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1typ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 8 ALA A 442
GLY A 426
ILE A 415
ILE A 437
ILE A 438
 None
 1.48A 1hshD-1typA:
undetectable		 1hshD-1typA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 1jffB-1typA:
undetectable		 1jffB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 8 GLY A  20
GLY A  16
GLY A  15
LEU A  17
 None
None
FAD  A 493 (-3.7A)
SPD  A 496 (-4.6A)
 0.66A 1qzzA-1typA:
2.3		 1qzzA-1typA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 ILE A  10
GLY A  11
GLY A  13
SER A  14
ALA A  46
 FAD  A 493 (-4.7A)
FAD  A 493 (-3.3A)
FAD  A 493 (-3.2A)
GSH  A 495 ( 3.5A)
FAD  A 493 (-3.2A)
 0.82A 1vq1B-1typA:
2.8		 1vq1B-1typA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 7 ALA A 284
ARG A 287
TYR A 183
PHE A 203
 None
FAD  A 493 ( 3.5A)
None
None
 1.17A 2ajvH-1typA:
undetectable
2ajvL-1typA:
undetectable		 2ajvH-1typA:
18.07
2ajvL-1typA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2hxfB-1typA:
undetectable		 2hxfB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2hxhB-1typA:
undetectable		 2hxhB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		6 / 12 GLY A  50
ALA A  12
GLY A  11
ALA A 159
LEU A  48
VAL A  55
 FAD  A 493 (-3.0A)
None
FAD  A 493 (-3.3A)
FAD  A 493 (-4.7A)
None
None
 1.45A 2nyuA-1typA:
3.5		 2nyuA-1typA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2p4nB-1typA:
undetectable		 2p4nB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 6 PHE A 122
PHE A 114
GLY A  13
GLY A  16
 None
None
FAD  A 493 (-3.2A)
None
 0.93A 2qr2A-1typA:
undetectable
2qr2B-1typA:
undetectable		 2qr2A-1typA:
20.51
2qr2B-1typA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 5 GLY A  13
GLY A  16
PHE A 122
PHE A 114
 FAD  A 493 (-3.2A)
None
None
None
 0.93A 2qr2A-1typA:
undetectable
2qr2B-1typA:
undetectable		 2qr2A-1typA:
20.51
2qr2B-1typA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 2wbeB-1typA:
undetectable		 2wbeB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.21A 3dcoB-1typA:
undetectable		 3dcoB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.20A 3edlB-1typA:
undetectable		 3edlB-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 149
LEU A  17
PHE A 122
LEU A  48
GLY A 127
 None
SPD  A 496 (-4.6A)
None
None
FAD  A 493 (-3.9A)
 1.18A 3iz0B-1typA:
undetectable		 3iz0B-1typA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 5 LEU A  17
GLY A  13
PHE A 122
ASN A  54
 SPD  A 496 (-4.6A)
FAD  A 493 (-3.2A)
None
None
 1.08A 3uq6B-1typA:
5.2		 3uq6B-1typA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 8 HIS A 428
VAL A 416
VAL A 391
ASP A 381
 None
 1.15A 3uy4A-1typA:
undetectable		 3uy4A-1typA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLY A 431
ASP A 432
ILE A 369
ASP A  71
LEU A 238
 None
 1.23A 4a81A-1typA:
undetectable		 4a81A-1typA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 TYR A 110
GLY A  16
ALA A  12
ILE A 325
GLU A 341
 GSH  A 497 ( 4.0A)
None
None
None
None
 1.21A 4azsA-1typA:
2.8		 4azsA-1typA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLY A  13
GLY A  49
ALA A  19
VAL A  33
VAL A  31
 FAD  A 493 (-3.2A)
None
None
None
None
 0.97A 4htfB-1typA:
2.4		 4htfB-1typA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLY A  13
GLY A  49
ALA A  46
ALA A 159
ASP A 327
 FAD  A 493 (-3.2A)
None
FAD  A 493 (-3.2A)
FAD  A 493 (-4.7A)
FAD  A 493 (-2.8A)
 1.13A 4kicA-1typA:
3.4		 4kicA-1typA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLY A  13
GLY A  49
ALA A  46
ALA A 159
ASP A 327
 FAD  A 493 (-3.2A)
None
FAD  A 493 (-3.2A)
FAD  A 493 (-4.7A)
FAD  A 493 (-2.8A)
 1.11A 4kicB-1typA:
3.1		 4kicB-1typA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 6 ARG A 290
GLY A 161
HIS A 166
ARG A 287
 FAD  A 493 ( 3.9A)
FAD  A 493 (-3.5A)
None
FAD  A 493 ( 3.5A)
 1.24A 4lajA-1typA:
undetectable
4lajB-1typA:
undetectable		 4lajA-1typA:
20.47
4lajB-1typA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 GLU A 379
ARG A 414
SER A 232
GLU A 380
TYR A 478
 None
 1.21A 4mx0A-1typA:
undetectable		 4mx0A-1typA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 ALA A  12
GLY A  13
GLY A  16
ILE A  34
PHE A 122
 None
FAD  A 493 (-3.2A)
None
FAD  A 493 ( 4.8A)
None
 1.00A 4obwB-1typA:
undetectable		 4obwB-1typA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 TYR A 386
GLY A 422
ALA A 420
ILE A 451
ILE A 415
 None
 1.12A 4uw0A-1typA:
3.1		 4uw0A-1typA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 7 VAL A  33
ILE A  34
LEU A 296
LEU A 129
 None
FAD  A 493 ( 4.8A)
None
None
 1.03A 4xo7A-1typA:
undetectable		 4xo7A-1typA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 8 ALA A 159
VAL A   9
GLY A  15
ALA A 338
GLY A 342
 FAD  A 493 (-4.7A)
None
FAD  A 493 (-3.7A)
FAD  A 493 ( 3.7A)
None
 1.39A 4zjzB-1typA:
undetectable		 4zjzB-1typA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 7 GLU A 379
ARG A 414
GLU A 393
ALA A 475
 None
 0.90A 4zz8A-1typA:
undetectable		 4zz8A-1typA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 7 GLU A 379
ARG A 414
TYR A 478
GLU A 393
 None
 0.97A 4zz8A-1typA:
undetectable		 4zz8A-1typA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 PRO A 336
THR A 348
ILE A 325
SER A 315
ASN A 340
 FAD  A 493 (-4.4A)
None
None
None
None
 1.33A 5hgcA-1typA:
undetectable		 5hgcA-1typA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 10 PHE A 122
ILE A  34
PHE A 114
GLY A  13
GLY A  16
 None
FAD  A 493 ( 4.8A)
None
FAD  A 493 (-3.2A)
None
 1.05A 5lbtA-1typA:
undetectable
5lbtB-1typA:
undetectable		 5lbtA-1typA:
20.21
5lbtB-1typA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 10 ALA A 442
CYH A 375
ALA A 449
GLY A 448
ASP A 358
 None
 1.16A 5lf3H-1typA:
undetectable
5lf3I-1typA:
undetectable		 5lf3H-1typA:
18.89
5lf3I-1typA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 11 ALA A 442
CYH A 375
ALA A 449
GLY A 448
ASP A 358
 None
 1.14A 5lf7H-1typA:
undetectable
5lf7I-1typA:
undetectable		 5lf7H-1typA:
18.89
5lf7I-1typA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 6 ASN A 132
ALA A 299
VAL A 319
ASP A 131
 None
 1.16A 5umd2-1typA:
undetectable
5umdF-1typA:
undetectable		 5umd2-1typA:
10.68
5umdF-1typA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 4 ASP A 432
SER A 406
SER A 404
ASN A  68
 None
 1.12A 6iblA-1typA:
0.0		 6iblA-1typA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		4 / 4 ASP A 432
SER A 406
SER A 404
ASN A  68
 None
 1.10A 6iblB-1typA:
0.0		 6iblB-1typA:
22.67