SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 5 LEU A  61
LEU A  50
LEU A  34
GLY A  31
 None
 1.01A 1a4lC-1tz9A:
4.0		 1a4lC-1tz9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 6 GLU A 286
ILE A  15
TYR A   8
GLY A  12
 None
 0.96A 1maaB-1tz9A:
undetectable
1maaD-1tz9A:
undetectable		 1maaB-1tz9A:
21.43
1maaD-1tz9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		3 / 3 ILE A  47
LEU A  50
VAL A  54
 None
 0.26A 1mz9B-1tz9A:
undetectable		 1mz9B-1tz9A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 GLY A 330
GLY A 319
ILE A  20
LEU A 333
GLY A 332
 None
 0.93A 3axzA-1tz9A:
undetectable		 3axzA-1tz9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 8 ASN A 224
LYS A 223
PRO A 211
PHE A 130
 None
 0.85A 3bjwD-1tz9A:
undetectable		 3bjwD-1tz9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		3 / 3 ASP A  13
GLY A 332
TYR A   8
 None
 0.79A 3w9tC-1tz9A:
undetectable		 3w9tC-1tz9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		3 / 3 ASP A  13
GLY A 332
TYR A   8
 None
 0.78A 3w9tG-1tz9A:
undetectable		 3w9tG-1tz9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 7 GLY A  31
THR A  32
ILE A  64
THR A 243
 None
 0.69A 4acaC-1tz9A:
2.1		 4acaC-1tz9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 5 TYR A 347
ILE A 343
TYR A 310
ILE A 314
 None
 0.92A 4jtpA-1tz9A:
undetectable		 4jtpA-1tz9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 8 ILE A 194
LEU A 228
VAL A 183
LEU A 186
 None
 1.00A 4r38B-1tz9A:
undetectable		 4r38B-1tz9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 9 ILE A 194
LEU A 228
VAL A 183
LEU A 186
ILE A 221
 None
 1.25A 4r38C-1tz9A:
undetectable		 4r38C-1tz9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 ILE A 202
GLY A  95
ILE A 194
MET A 204
VAL A 193
 None
 1.06A 5n0tA-1tz9A:
undetectable		 5n0tA-1tz9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 ILE A 202
GLY A  95
ILE A 194
MET A 204
VAL A 193
 None
 1.08A 5n0wB-1tz9A:
undetectable		 5n0wB-1tz9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 ILE A 202
GLY A  95
ILE A 194
MET A 204
VAL A 193
 None
 1.09A 5n0xA-1tz9A:
undetectable		 5n0xA-1tz9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 ILE A 202
GLY A  95
ILE A 194
MET A 204
VAL A 193
 None
 1.08A 5n4iA-1tz9A:
undetectable		 5n4iA-1tz9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 8 THR A  27
GLY A  28
ALA A  60
GLY A   4
 None
 0.74A 5vw9A-1tz9A:
undetectable		 5vw9A-1tz9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 11 GLY A 332
TYR A   8
ARG A 336
MET A 328
GLY A 330
 None
 1.29A 5yjsA-1tz9A:
undetectable		 5yjsA-1tz9A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1tz9 MANNONATE
DEHYDRATASE
(Enterococcus
faecalis) 		3 / 3 GLU A 214
ASP A 209
PRO A 212
 None
 0.80A 6berA-1tz9A:
undetectable		 6berA-1tz9A:
2.56