SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M4I_A_KANA500_1 (AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERA SE)	1tza	APAG PROTEIN (Shewanella oneidensis)	4 / 8	ASP A 5 GLU A 41 GLY A 40 SER A 104	ASP A 5 ( 0.6A) GLU A 41 ( 0.6A) GLY A 40 ( 0.0A) SER A 104 ( 0.0A)	0.89A	1m4iA-1tzaA: undetectable	1m4iA-1tzaA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TKQ_A_DVAA6_0 (MINI-GRAMICIDIN A)	1tza	APAG PROTEIN (Shewanella oneidensis)	3 / 3	ALA A 66 VAL A 68 TRP A 51	ALA A 66 ( 0.0A) VAL A 68 ( 0.6A) TRP A 51 ( 0.5A)	0.75A	1tkqA-1tzaA: undetectable	1tkqA-1tzaA: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	1tza	APAG PROTEIN (Shewanella oneidensis)	4 / 8	TYR A 28 PHE A 30 ALA A 56 LEU A 124	TYR A 28 ( 1.3A) PHE A 30 ( 1.3A) ALA A 56 ( 0.0A) LEU A 124 ( 0.6A)	1.14A	1x8vA-1tzaA: undetectable	1x8vA-1tzaA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RGL_A_GLYA301_0 (GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT)	1tza	APAG PROTEIN (Shewanella oneidensis)	4 / 8	ALA A 66 GLY A 65 THR A 48 GLN A 64	ALA A 66 ( 0.0A) GLY A 65 ( 0.0A) THR A 48 ( 0.8A) GLN A 64 ( 0.6A)	0.92A	3rglA-1tzaA: undetectable	3rglA-1tzaA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_E_PFLE409_1 (PROTON-GATED ION CHANNEL)	1tza	APAG PROTEIN (Shewanella oneidensis)	4 / 8	ILE A 52 TYR A 100 THR A 99 ILE A 114	ILE A 52 ( 0.4A) TYR A 100 ( 1.3A) THR A 99 ( 0.8A) ILE A 114 ( 0.6A)	0.70A	5mzrE-1tzaA: 3.3	5mzrE-1tzaA: 18.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1M4I_A_KANA500_1","AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE","1tza","APAG PROTEIN","Shewanella oneidensis",4,"ASP A   5;GLU A  41;GLY A  40;SER A 104","ASP A   5 ( 0.6A);GLU A  41 ( 0.6A);GLY A  40 ( 0.0A);SER A 104 ( 0.0A)","0.89A","1m4iA-1tzaA:undetectable","1m4iA-1tzaA:19.34"],["1TKQ_A_DVAA6_0","MINI-GRAMICIDIN A","1tza","APAG PROTEIN","Shewanella oneidensis",3,"ALA A  66;VAL A  68;TRP A  51","ALA A  66 ( 0.0A);VAL A  68 ( 0.6A);TRP A  51 ( 0.5A)","0.75A","1tkqA-1tzaA:undetectable","1tkqA-1tzaA:9.52"],["1X8V_A_ESLA471_1","CYTOCHROME P450 51","1tza","APAG PROTEIN","Shewanella oneidensis",4,"TYR A  28;PHE A  30;ALA A  56;LEU A 124","TYR A  28 ( 1.3A);PHE A  30 ( 1.3A);ALA A  56 ( 0.0A);LEU A 124 ( 0.6A)","1.14A","1x8vA-1tzaA:undetectable","1x8vA-1tzaA:14.25"],["3RGL_A_GLYA301_0","GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT","1tza","APAG PROTEIN","Shewanella oneidensis",4,"ALA A  66;GLY A  65;THR A  48;GLN A  64","ALA A  66 ( 0.0A);GLY A  65 ( 0.0A);THR A  48 ( 0.8A);GLN A  64 ( 0.6A)","0.92A","3rglA-1tzaA:undetectable","3rglA-1tzaA:18.85"],["5MZR_E_PFLE409_1","PROTON-GATED ION CHANNEL","1tza","APAG PROTEIN","Shewanella oneidensis",4,"ILE A  52;TYR A 100;THR A  99;ILE A 114","ILE A  52 ( 0.4A);TYR A 100 ( 1.3A);THR A  99 ( 0.8A);ILE A 114 ( 0.6A)","0.70A","5mzrE-1tzaA:3.3","5mzrE-1tzaA:18.38"]]