SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		3 / 3 ASP A  53
TYR A 195
GLU A 188
 GOL  A 801 (-2.8A)
GOL  A 801 (-3.5A)
None
 0.84A 1vm1A-1tzbA:
undetectable		 1vm1A-1tzbA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.12A 2h77A-1tzbA:
undetectable		 2h77A-1tzbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.09A 2h79A-1tzbA:
undetectable		 2h79A-1tzbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 10 ILE A 112
LEU A  82
VAL A 148
ALA A 145
VAL A  68
 None
 1.05A 2nnjA-1tzbA:
0.0		 2nnjA-1tzbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  42
LEU A  40
PHE A  21
VAL A 126
VAL A 128
 None
 1.13A 2ygpA-1tzbA:
undetectable		 2ygpA-1tzbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.08A 3gwsX-1tzbA:
undetectable		 3gwsX-1tzbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  54
ALA A 145
VAL A 128
ILE A  15
VAL A  51
 None
 0.96A 3ucbB-1tzbA:
undetectable		 3ucbB-1tzbA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		4 / 8 THR A 125
LEU A 118
GLY A  90
VAL A 128
 None
 0.77A 4c9nA-1tzbA:
undetectable		 4c9nA-1tzbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		4 / 8 ILE A  42
ILE A 112
ALA A 144
VAL A  51
 None
 0.67A 4jltA-1tzbA:
0.0		 4jltA-1tzbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		4 / 8 LEU A 146
LEU A 142
ILE A 155
VAL A  68
 None
 0.85A 4klaA-1tzbA:
undetectable		 4klaA-1tzbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.11A 4lnwA-1tzbA:
undetectable		 4lnwA-1tzbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 155
ALA A 150
ALA A 145
LEU A 146
ILE A  42
 None
 1.11A 4lnxA-1tzbA:
undetectable		 4lnxA-1tzbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		3 / 3 LEU A   4
ASP A   7
TYR A   8
 None
 0.35A 4qc6B-1tzbA:
undetectable		 4qc6B-1tzbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 9 ILE A 184
PHE A 269
LEU A 232
LEU A 270
ASP A  57
 None
 1.30A 4qopB-1tzbA:
undetectable		 4qopB-1tzbA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 9 ALA A 150
ILE A  42
LEU A  40
ILE A  84
ILE A 112
 None
 0.96A 5nunA-1tzbA:
0.0		 5nunA-1tzbA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A
HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		4 / 4 GLU A 203
ARG A 135
ARG A 196
GLU A 200
 None
 1.46A 5odcB-1tzbA:
0.0
5odcC-1tzbA:
0.0
5odcG-1tzbA:
2.2		 5odcB-1tzbA:
23.51
5odcC-1tzbA:
20.60
5odcG-1tzbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  84
VAL A  19
LEU A 146
THR A 143
LEU A 142
 None
 1.25A 5tiwA-1tzbA:
2.5		 5tiwA-1tzbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 10 VAL A  50
GLY A  49
GLY A  44
LEU A 146
ILE A 112
 None
 1.01A 5vm8B-1tzbA:
undetectable		 5vm8B-1tzbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  49
SER A  89
GLY A  46
GLY A  47
PRO A 134
 None
SO4  A 709 (-3.1A)
None
SO4  A 709 ( 4.8A)
SO4  A 709 (-4.2A)
 0.88A 5wyqA-1tzbA:
undetectable		 5wyqA-1tzbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  49
SER A  89
GLY A  46
GLY A  47
PRO A 134
 None
SO4  A 709 (-3.1A)
None
SO4  A 709 ( 4.8A)
SO4  A 709 (-4.2A)
 0.90A 5wyqB-1tzbA:
2.1		 5wyqB-1tzbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  49
SER A  89
GLY A  46
GLY A  47
PRO A 134
 None
SO4  A 709 (-3.1A)
None
SO4  A 709 ( 4.8A)
SO4  A 709 (-4.2A)
 0.90A 5zhmB-1tzbA:
2.0		 5zhmB-1tzbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL
(Pyrobaculum
aerophilum) 		4 / 8 GLU A 216
THR A 248
TRP A 221
ASN A 220
 None
 1.10A 6c71B-1tzbA:
undetectable		 6c71B-1tzbA:
13.47