SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 7 VAL A 193
VAL A 258
ARG A  53
CYH A 196
 None
None
None
PLP  A 401 (-3.8A)
 1.22A 1t46A-1tzmA:
undetectable		 1t46A-1tzmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		5 / 12 GLY A 161
CYH A 162
TYR A 156
LEU A  70
VAL A  87
 C2N  A 501 (-3.4A)
None
None
None
None
 1.27A 3g9eA-1tzmA:
undetectable		 3g9eA-1tzmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		5 / 11 TYR A 331
ASP A 291
TYR A 268
TYR A 294
LEU A 270
 None
PLP  A 401 ( 4.9A)
None
PLP  A 401 (-3.9A)
None
 1.21A 4kysB-1tzmA:
0.3		 4kysB-1tzmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		3 / 3 SER A 298
TYR A 319
ASP A 291
 None
None
PLP  A 401 ( 4.9A)
 0.77A 4rp8C-1tzmA:
undetectable		 4rp8C-1tzmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		5 / 12 THR A 199
GLN A  80
THR A  81
VAL A  84
GLU A 100
 PLP  A 401 ( 2.8A)
None
None
None
None
 0.95A 4s0vA-1tzmA:
undetectable		 4s0vA-1tzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 6 ARG A   8
GLY A 171
THR A  12
GLU A  56
 None
 1.05A 5btaA-1tzmA:
undetectable
5btaB-1tzmA:
undetectable
5btaC-1tzmA:
undetectable		 5btaA-1tzmA:
21.57
5btaB-1tzmA:
23.66
5btaC-1tzmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 8 VAL A 179
GLU A  39
GLY A 174
GLY A 205
 None
 0.78A 5e26C-1tzmA:
1.9
5e26D-1tzmA:
1.9		 5e26C-1tzmA:
22.69
5e26D-1tzmA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 4 GLU A  61
PRO A  60
ILE A  59
LEU A  58
 None
 1.19A 5m45A-1tzmA:
undetectable		 5m45A-1tzmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 4 GLU A  61
PRO A  60
ILE A  59
LEU A  58
 None
 1.18A 5m45G-1tzmA:
0.0		 5m45G-1tzmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		4 / 4 GLU A  61
PRO A  60
ILE A  59
LEU A  58
 None
 1.22A 5m45J-1tzmA:
0.0		 5m45J-1tzmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Pseudomonas
sp.
ACP) 		3 / 3 ALA A 278
VAL A 194
TYR A 319
 None
 0.66A 5zmqH-1tzmA:
undetectable		 5zmqH-1tzmA:
19.94