SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU a1069
MET a1078
LEU a1080
GLN a1067
 None
 1.47A 1p93D-1tzna:
undetectable		 1p93D-1tzna:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 SER a1081
ILE a1083
ALA a1127
ALA a1134
 None
 0.96A 1w0gA-1tzna:
undetectable		 1w0gA-1tzna:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 7 TYR a1046
ALA a1171
SER a1140
THR a1139
 None
 1.04A 2i91A-1tzna:
12.8		 2i91A-1tzna:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 7 TYR a1046
ALA a1171
SER a1140
THR a1139
 None
 1.03A 2i91B-1tzna:
12.0		 2i91B-1tzna:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 PHE a1043
PHE a1073
LEU a1069
PHE a1065
 None
 1.30A 2y69C-1tzna:
0.1
2y69J-1tzna:
undetectable		 2y69C-1tzna:
20.80
2y69J-1tzna:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 PHE a1043
PHE a1073
LEU a1069
PHE a1065
 None
 1.27A 2y69P-1tzna:
undetectable
2y69W-1tzna:
undetectable		 2y69P-1tzna:
20.80
2y69W-1tzna:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 PHE a1043
PHE a1073
LEU a1069
PHE a1065
 None
 1.25A 3abmP-1tzna:
0.0
3abmW-1tzna:
0.0		 3abmP-1tzna:
20.80
3abmW-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 PHE a1043
ARG a1040
LEU a1045
SER a1140
 None
 0.97A 3vlnA-1tzna:
undetectable		 3vlnA-1tzna:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 ASP a1050
SER a1086
GLY a1116
ASP a1148
 None
 1.40A 3w9tB-1tzna:
undetectable		 3w9tB-1tzna:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 ASP a1050
SER a1086
GLY a1116
ASP a1148
 None
 1.41A 3w9tC-1tzna:
undetectable		 3w9tC-1tzna:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 5 ASP a1050
SER a1086
GLY a1116
ASP a1148
 None
 1.41A 3w9tD-1tzna:
undetectable		 3w9tD-1tzna:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU a1124
LEU a1045
ASN a1128
PHE a1043
ALA a1171
 None
 1.27A 5y7pD-1tzna:
0.0		 5y7pD-1tzna:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.08A 5z84P-1tzna:
0.1
5z84W-1tzna:
undetectable		 5z84P-1tzna:
20.80
5z84W-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.14A 5z85P-1tzna:
0.0
5z85W-1tzna:
undetectable		 5z85P-1tzna:
20.80
5z85W-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.06A 5z86C-1tzna:
0.1
5z86J-1tzna:
undetectable		 5z86C-1tzna:
20.80
5z86J-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.11A 5z86P-1tzna:
0.0
5z86W-1tzna:
undetectable		 5z86P-1tzna:
20.80
5z86W-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.09A 5zcoP-1tzna:
undetectable
5zcoW-1tzna:
0.0		 5zcoP-1tzna:
20.80
5zcoW-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.01A 5zcpC-1tzna:
0.0
5zcpJ-1tzna:
undetectable		 5zcpC-1tzna:
20.80
5zcpJ-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.05A 5zcpP-1tzna:
0.1
5zcpW-1tzna:
undetectable		 5zcpP-1tzna:
20.80
5zcpW-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens) 		4 / 8 LYS a1150
GLY a1149
GLY a1177
GLU a1187
 None
 0.72A 6mdqA-1tzna:
1.6		 6mdqA-1tzna:
20.23