SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1tzq EQUINATOXIN II
(Actinia
equina) 		5 / 12 VAL A  65
LEU A  72
LEU A  71
HIS A 175
GLU A 173
 None
 1.42A 1mmkA-1tzqA:
undetectable		 1mmkA-1tzqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 6 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.50A 1nsiC-1tzqA:
0.0
1nsiD-1tzqA:
0.0		 1nsiC-1tzqA:
17.78
1nsiD-1tzqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1tzq EQUINATOXIN II
(Actinia
equina) 		3 / 3 GLY A  11
GLU A  40
ASP A  10
 None
 0.67A 2b25B-1tzqA:
undetectable		 2b25B-1tzqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.47A 2nsiA-1tzqA:
undetectable
2nsiB-1tzqA:
undetectable		 2nsiA-1tzqA:
17.78
2nsiB-1tzqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.50A 2nsiA-1tzqA:
undetectable
2nsiB-1tzqA:
undetectable		 2nsiA-1tzqA:
17.78
2nsiB-1tzqA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.48A 3e7gA-1tzqA:
undetectable
3e7gB-1tzqA:
undetectable		 3e7gA-1tzqA:
18.35
3e7gB-1tzqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.48A 3e7gA-1tzqA:
undetectable
3e7gB-1tzqA:
undetectable		 3e7gA-1tzqA:
18.35
3e7gB-1tzqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.50A 3e7gC-1tzqA:
undetectable
3e7gD-1tzqA:
undetectable		 3e7gC-1tzqA:
18.35
3e7gD-1tzqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 6 VAL A 102
LEU A  26
ILE A  18
LEU A  90
 None
 0.96A 3kk6A-1tzqA:
undetectable		 3kk6A-1tzqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1tzq EQUINATOXIN II
(Actinia
equina) 		5 / 8 VAL A 102
LEU A  90
ILE A 174
VAL A  37
LEU A  71
 None
 1.34A 3kp6A-1tzqA:
undetectable
3kp6B-1tzqA:
undetectable		 3kp6A-1tzqA:
21.16
3kp6B-1tzqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 TYR A 122
ASN A 118
LEU A 136
SER A 141
 None
 1.39A 3lslA-1tzqA:
undetectable
3lslD-1tzqA:
undetectable		 3lslA-1tzqA:
20.16
3lslD-1tzqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1tzq EQUINATOXIN II
(Actinia
equina) 		4 / 7 SER A 141
TYR A 122
ASN A 118
LEU A 136
 None
 1.44A 3lslA-1tzqA:
undetectable
3lslD-1tzqA:
undetectable		 3lslA-1tzqA:
20.16
3lslD-1tzqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1tzq EQUINATOXIN II
(Actinia
equina) 		5 / 11 VAL A  29
LEU A  26
VAL A 106
GLY A  85
ALA A  86
 None
 1.20A 3pghB-1tzqA:
undetectable		 3pghB-1tzqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tzq EQUINATOXIN II
(Actinia
equina) 		3 / 3 TYR A 110
TYR A 133
SER A  54
 None
 0.61A 5iktB-1tzqA:
undetectable		 5iktB-1tzqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1tzq EQUINATOXIN II
(Actinia
equina) 		3 / 3 LYS A 125
LEU A  48
ARG A 127
 None
 0.82A 5yw0A-1tzqA:
undetectable		 5yw0A-1tzqA:
20.44