SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 8 PHE A  67
GLY A 113
VAL A 147
PHE A  38
 None
 0.93A 1gsfC-1tzsA:
undetectable		 1gsfC-1tzsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 SER A 299
ASN A  19
LEU A 233
MET A  23
LEU A 288
 None
 1.31A 1lhuA-1tzsA:
0.0		 1lhuA-1tzsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 8 SER A 299
ASN A  19
MET A  23
LEU A 288
 None
 0.95A 1lhvA-1tzsA:
undetectable		 1lhvA-1tzsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 5 ASP A 319
GLY A  45
VAL A 164
ILE A 322
 None
 0.96A 2aoiA-1tzsA:
8.2		 2aoiA-1tzsA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ASP A  43
GLY A  45
ASN A  48
ILE A  84
ILE A 131
 None
 0.58A 2q64A-1tzsA:
8.2		 2q64A-1tzsA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ASP A  43
GLY A  45
ASN A  48
ILE A  84
ILE A 131
 None
 0.55A 2q64B-1tzsA:
7.9		 2q64B-1tzsA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ASP A  43
GLY A  45
ASN A  48
ILE A  84
ILE A 131
 None
 0.51A 2qakA-1tzsA:
8.2		 2qakA-1tzsA:
15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		8 / 12 ASP A  43
GLY A  45
SER A  46
TYR A  86
PHE A 128
ASP A 228
GLY A 230
SER A 232
 None
 0.65A 2v0zC-1tzsA:
41.8		 2v0zC-1tzsA:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		7 / 12 ASP A  43
GLY A  45
PHE A 128
ASP A 228
GLY A 230
SER A 232
ILE A 307
 None
 0.92A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ASP A 228
GLY A 230
ALA A 311
ASP A  43
GLY A  45
 None
 0.56A 2v0zO-1tzsA:
42.4		 2v0zO-1tzsA:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 MET A 166
GLU A  24
ASN A  19
 None
 1.08A 3a27A-1tzsA:
undetectable		 3a27A-1tzsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 ASP A 290
LEU A 288
GLN A 245
 None
 0.67A 3g4lA-1tzsA:
undetectable		 3g4lA-1tzsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 HIS A 187
TYR A 326
LEU A 192
ILE A 179
GLY A 181
 None
 1.25A 3kk6B-1tzsA:
undetectable		 3kk6B-1tzsA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		6 / 12 ASP A  22
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
 None
 0.84A 3prsA-1tzsA:
8.6		 3prsA-1tzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ASP A  22
ASP A  43
ILE A 226
THR A 231
ILE A 316
 None
 1.06A 3pwwA-1tzsA:
8.9		 3pwwA-1tzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 8 GLY A  45
SER A  46
TYR A  86
ASP A 228
 None
 0.41A 3pwwA-1tzsA:
8.9		 3pwwA-1tzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1tzs CATHEPSIN E
(Homo
sapiens) 		6 / 12 ILE A  41
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
 None
 0.32A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1tzs CATHEPSIN E
(Homo
sapiens) 		6 / 12 ILE A 131
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
 None
 1.16A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1tzs CATHEPSIN E
(Homo
sapiens) 		6 / 12 ILE A 226
ASP A 228
GLY A 230
ILE A 307
ASP A  43
ILE A 131
 None
 0.73A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 6 LEU A 281
VAL A 270
PHE A 302
VAL A 320
 None
 1.06A 3soaA-1tzsA:
undetectable		 3soaA-1tzsA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ILE A  41
ASP A  43
GLY A  45
ASP A 228
ILE A 316
 None
 0.29A 3tneA-1tzsA:
33.8		 3tneA-1tzsA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ILE A 226
ASP A 228
GLY A 230
ASP A  43
ILE A 131
 None
 0.65A 3tneA-1tzsA:
33.8		 3tneA-1tzsA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ILE A  41
ASP A  43
GLY A  45
ASP A 228
ILE A 316
 None
 0.27A 3tneB-1tzsA:
33.8		 3tneB-1tzsA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ILE A 226
ASP A 228
GLY A 230
ASP A  43
ILE A 131
 None
 0.66A 3tneB-1tzsA:
33.8		 3tneB-1tzsA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 7 SER A  46
TYR A  86
ILE A 131
THR A 231
 None
 0.57A 3tneB-1tzsA:
33.8		 3tneB-1tzsA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 TYR A  20
GLY A 133
GLY A  45
ILE A  41
ALA A 140
 None
 1.14A 4a6dA-1tzsA:
undetectable		 4a6dA-1tzsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 8 ASP A  98
ILE A  31
GLY A  32
VAL A  40
 None
 0.74A 4acbB-1tzsA:
undetectable
4acbC-1tzsA:
undetectable		 4acbB-1tzsA:
20.52
4acbC-1tzsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 GLU A  24
ASP A  43
GLY A 318
SER A 232
GLN A 303
 None
 1.09A 4djeB-1tzsA:
undetectable		 4djeB-1tzsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 GLU A  24
ASP A  43
GLY A 318
SER A 232
GLN A 303
 None
 1.40A 4djfB-1tzsA:
undetectable		 4djfB-1tzsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 ILE A 234
THR A 235
VAL A 164
ASP A 319
ILE A 322
 None
 1.29A 4i41A-1tzsA:
undetectable		 4i41A-1tzsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		4 / 5 ILE A  41
ASN A  19
TYR A  86
ILE A 131
 None
 1.04A 4jtpA-1tzsA:
undetectable		 4jtpA-1tzsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.70A 4k8cA-1tzsA:
undetectable		 4k8cA-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.68A 4kahA-1tzsA:
undetectable		 4kahA-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.69A 4kahB-1tzsA:
undetectable		 4kahB-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.68A 4kanA-1tzsA:
undetectable		 4kanA-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.71A 4kanB-1tzsA:
undetectable		 4kanB-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.72A 4kbeA-1tzsA:
undetectable		 4kbeA-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.70A 4kbeB-1tzsA:
undetectable		 4kbeB-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.70A 4lbgA-1tzsA:
undetectable		 4lbgA-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 SER A  46
TYR A  86
PRO A 146
 None
 0.68A 4lbgB-1tzsA:
undetectable		 4lbgB-1tzsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 PHE A  42
GLU A 177
TYR A 165
ALA A 174
GLY A 173
 None
 1.49A 4oadA-1tzsA:
undetectable		 4oadA-1tzsA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		3 / 3 ASP A 228
ASP A  43
ASN A  48
 None
 0.61A 4q5mA-1tzsA:
10.0		 4q5mA-1tzsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 12 GLY A  45
SER A  46
LEU A  17
LEU A  21
GLU A  24
 None
 1.04A 5nwwA-1tzsA:
undetectable		 5nwwA-1tzsA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 11 GLY A 130
LEU A  17
SER A 115
PHE A 123
HIS A  64
 None
 1.28A 6qgbA-1tzsA:
0.0		 6qgbA-1tzsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 10 GLY A 130
LEU A  17
SER A 115
PHE A 123
HIS A  64
 None
 1.27A 6qgbB-1tzsA:
undetectable		 6qgbB-1tzsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1tzs CATHEPSIN E
(Homo
sapiens) 		5 / 10 GLY A 130
LEU A  17
SER A 115
PHE A 123
HIS A  64
 None
 1.27A 6qgbD-1tzsA:
undetectable		 6qgbD-1tzsA:
20.27