SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1tzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		4 / 8 ARG A  86
ASP A 128
GLY A 125
PHE A 122
 None
 0.92A 2tsrB-1tzxA:
undetectable		 2tsrB-1tzxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		5 / 12 ALA A 107
SER A  78
LEU A  77
ILE A 126
THR A 103
 None
 1.11A 2w3vA-1tzxA:
undetectable		 2w3vA-1tzxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		3 / 3 LEU A  58
ARG A  82
ILE A  61
 None
 0.61A 2xn5B-1tzxA:
undetectable		 2xn5B-1tzxA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		5 / 12 ILE A 130
ALA A  88
LEU A  77
LEU A  69
ILE A 126
 None
 1.02A 4m2xA-1tzxA:
undetectable		 4m2xA-1tzxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		5 / 12 ILE A 130
ALA A  88
LEU A  77
LEU A  69
ILE A 126
 None
 1.02A 4m2xC-1tzxA:
undetectable		 4m2xC-1tzxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		5 / 12 ILE A 130
ALA A  88
LEU A  77
LEU A  69
ILE A 126
 None
 1.05A 4m2xE-1tzxA:
undetectable		 4m2xE-1tzxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG
(Thermotoga
maritima) 		4 / 8 LEU A  64
LEU A  85
ILE A  98
THR A 103
 None
 1.06A 5ljbA-1tzxA:
undetectable		 5ljbA-1tzxA:
20.00