SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 6 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.83A 3wg7A-1u00A:
2.4
3wg7J-1u00A:
undetectable		 3wg7A-1u00A:
17.75
3wg7J-1u00A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 5 VAL A 524
ARG A 527
MET A 528
GLU A 531
 None
 1.20A 4hojA-1u00A:
0.0		 4hojA-1u00A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 5 VAL A 471
LEU A 398
ILE A 435
LEU A 456
 None
 0.86A 4mghA-1u00A:
undetectable		 4mghA-1u00A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 7 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.82A 5b1aA-1u00A:
2.4
5b1aJ-1u00A:
undetectable		 5b1aA-1u00A:
17.75
5b1aJ-1u00A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 7 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.85A 5b3sA-1u00A:
2.3
5b3sJ-1u00A:
undetectable		 5b3sA-1u00A:
17.75
5b3sJ-1u00A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		3 / 3 VAL A 405
GLN A 439
CYH A 448
 None
 0.63A 5icxA-1u00A:
undetectable
5icxE-1u00A:
undetectable		 5icxA-1u00A:
21.25
5icxE-1u00A:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1u00 CHAPERONE PROTEIN
HSCA
(Escherichia
coli) 		4 / 7 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.77A 5zcqA-1u00A:
2.4
5zcqJ-1u00A:
undetectable		 5zcqA-1u00A:
17.75
5zcqJ-1u00A:
13.11