SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASP A   9
TYR A 146
ARG A 155
THR A  45
 NA  A 241 (-3.6A)
None
None
None
 1.11A 1ceaA-1u02A:
undetectable
1ceaB-1u02A:
undetectable		 1ceaA-1u02A:
15.90
1ceaB-1u02A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ASP A 183
ASP A   7
TYR A 146
ARG A 155
 MG  A 240 ( 4.5A)
MG  A 240 (-2.5A)
None
None
 1.25A 1cebB-1u02A:
undetectable		 1cebB-1u02A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 VAL A 115
TYR A  93
ILE A 134
TRP A  99
LEU A 106
 None
 1.46A 1ihiA-1u02A:
0.2		 1ihiA-1u02A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 5 LEU A  35
ILE A   4
LEU A   3
SER A   2
ARG A 172
 None
 1.42A 2byoA-1u02A:
0.0		 2byoA-1u02A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.42A 2hrcB-1u02A:
2.1		 2hrcB-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.43A 2pnjB-1u02A:
2.3		 2pnjB-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.49A 2qd2A-1u02A:
2.1		 2qd2A-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ILE A  32
ARG A 216
LEU A 219
LEU A  56
 None
 0.99A 2rlfA-1u02A:
undetectable
2rlfD-1u02A:
undetectable		 2rlfA-1u02A:
10.91
2rlfD-1u02A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ASP A 192
ARG A 166
ARG A 169
ILE A 176
 None
 1.15A 2yfbA-1u02A:
undetectable		 2yfbA-1u02A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.46A 3hcoA-1u02A:
2.1		 3hcoA-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 VAL A 115
TYR A  93
ILE A 134
TRP A  99
LEU A 106
 None
 1.46A 4jqaB-1u02A:
1.5		 4jqaB-1u02A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 VAL A 115
TYR A  93
ILE A 134
TRP A  99
LEU A 106
 None
 1.46A 4jtqB-1u02A:
0.5		 4jtqB-1u02A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ALA A 164
ILE A  52
GLY A  46
SER A  82
 None
 0.86A 4r20A-1u02A:
undetectable		 4r20A-1u02A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQL_A_KANA203_1
(2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ASP A 179
ASP A   7
ASP A 183
ILE A  63
GLU A 153
 MG  A 240 (-2.5A)
MG  A 240 (-2.5A)
MG  A 240 ( 4.5A)
None
None
 1.29A 4wqlA-1u02A:
0.1		 4wqlA-1u02A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASP A 179
ASP A   7
ASP A 183
ILE A  63
 MG  A 240 (-2.5A)
MG  A 240 (-2.5A)
MG  A 240 ( 4.5A)
None
 1.02A 4xjeA-1u02A:
undetectable		 4xjeA-1u02A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 LYS A 197
GLY A 178
ASN A 190
ALA A 189
HIS A 204
 None
 1.46A 5arfA-1u02A:
0.0		 5arfA-1u02A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A   4
LEU A 225
GLY A 178
LEU A  12
THR A  11
 None
 1.20A 5byjA-1u02A:
undetectable		 5byjA-1u02A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASP A 179
ASP A   7
ASP A 183
ILE A  63
 MG  A 240 (-2.5A)
MG  A 240 (-2.5A)
MG  A 240 ( 4.5A)
None
 1.03A 5cfsA-1u02A:
undetectable		 5cfsA-1u02A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1742_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 ASP A 179
LYS A 197
THR A 182
ASP A 183
 MG  A 240 (-2.5A)
None
None
MG  A 240 ( 4.5A)
 1.39A 5g5hC-1u02A:
0.0		 5g5hC-1u02A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ASP A  95
VAL A 100
ILE A 108
TYR A 117
ILE A 137
 None
 1.23A 5hw8D-1u02A:
undetectable		 5hw8D-1u02A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 ASP A  95
VAL A 100
ILE A 108
TYR A 117
ILE A 137
 None
 1.19A 5hw8E-1u02A:
undetectable		 5hw8E-1u02A:
22.17