SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 11 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.13A 1akdA-1u05A:
undetectable		 1akdA-1u05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 9 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.19A 1dz8A-1u05A:
undetectable		 1dz8A-1u05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 9 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.22A 1dz8B-1u05A:
undetectable		 1dz8B-1u05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 9 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.19A 1dz9B-1u05A:
undetectable		 1dz9B-1u05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 8 ARG A 115
LEU A 150
PRO A  96
VAL A  15
GLY A  14
 None
 1.46A 1hrkB-1u05A:
undetectable		 1hrkB-1u05A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 7 GLU A  49
MET A   1
PHE A 225
ALA A  57
 None
 1.32A 1linA-1u05A:
undetectable		 1linA-1u05A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 7 LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 0.99A 1t88A-1u05A:
undetectable		 1t88A-1u05A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		3 / 3 GLN A 185
ILE A 184
TYR A 190
 None
 0.67A 1vifA-1u05A:
undetectable		 1vifA-1u05A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 11 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.13A 2a1nA-1u05A:
undetectable		 2a1nA-1u05A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 8 LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 0.90A 2a1oA-1u05A:
undetectable		 2a1oA-1u05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 9 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.18A 2a1oB-1u05A:
undetectable		 2a1oB-1u05A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 10 PHE A 112
LEU A 130
VAL A 134
GLY A 133
VAL A 205
 None
 1.16A 2cp4A-1u05A:
undetectable		 2cp4A-1u05A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 12 PHE A 172
PHE A 112
THR A 138
VAL A 134
GLY A 129
 None
 1.19A 2ve3B-1u05A:
undetectable		 2ve3B-1u05A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		5 / 11 LEU A 153
LEU A 130
ALA A 198
LEU A 202
VAL A 123
 None
 1.31A 3e22B-1u05A:
undetectable		 3e22B-1u05A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 8 LEU A 135
ARG A 199
SER A 238
GLY A 212
 None
 1.10A 3hcrA-1u05A:
undetectable		 3hcrA-1u05A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 5 LEU A 130
GLY A 129
PHE A 172
ARG A 201
 None
 0.94A 3smtA-1u05A:
undetectable		 3smtA-1u05A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		3 / 3 TYR A 195
GLY A 158
PRO A 159
 None
 0.73A 4qwpA-1u05A:
undetectable		 4qwpA-1u05A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 7 PRO A   7
SER A  20
ASP A  32
THR A 233
 None
 1.30A 4uacA-1u05A:
undetectable		 4uacA-1u05A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		4 / 8 ALA A 101
LEU A  36
LEU A  60
LEU A  54
 None
 0.66A 5jqbA-1u05A:
undetectable
5jqbB-1u05A:
undetectable		 5jqbA-1u05A:
21.45
5jqbB-1u05A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN
(Shigella
flexneri) 		3 / 3 ILE A  23
ASN A 221
CYH A 216
 None
 0.81A 6bp4A-1u05A:
undetectable		 6bp4A-1u05A:
21.29