SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 8 ALA A  25
LEU A 183
LEU A 182
LEU A  39
ALA A  38
 None
 1.50A 1e7cA-1u0mA:
undetectable		 1e7cA-1u0mA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 VAL A 269
LEU A 329
SER A 262
VAL A 286
PHE A 291
 None
 1.42A 1fdwA-1u0mA:
undetectable		 1fdwA-1u0mA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 ALA A 249
GLU A 252
LEU A 253
MET A 341
 None
 0.81A 1hk2A-1u0mA:
undetectable		 1hk2A-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 183
LEU A 182
LEU A  39
LEU A  37
 None
 0.95A 2ab2B-1u0mA:
0.0		 2ab2B-1u0mA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 THR A 338
GLY A 142
GLY A 332
HIS A 270
ILE A 162
 None
 1.05A 2b25A-1u0mA:
undetectable		 2b25A-1u0mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 ILE A 133
GLY A 108
ASN A  69
PHE A  65
TYR A 224
 None
None
None
None
15P  A1000 (-4.9A)
 1.21A 2piwA-1u0mA:
undetectable		 2piwA-1u0mA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 136
GLY A 142
ILE A 102
ILE A 133
 None
 0.77A 2q9rA-1u0mA:
undetectable		 2q9rA-1u0mA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 11 ARG A  86
LEU A 114
ILE A 192
ALA A 164
LEU A 161
 None
 1.16A 2v0mA-1u0mA:
undetectable		 2v0mA-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 9 ARG A  86
LEU A 114
ILE A 192
ALA A 164
LEU A 161
 None
 1.22A 2v0mB-1u0mA:
0.0		 2v0mB-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 ILE A 162
LEU A 310
ARG A 147
GLY A 142
 None
 0.91A 2vdbA-1u0mA:
undetectable		 2vdbA-1u0mA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 VAL A  80
ALA A 164
ILE A 162
ILE A  98
ILE A  84
 None
 1.16A 3clbD-1u0mA:
0.6		 3clbD-1u0mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 GLY A 191
GLY A 189
THR A 297
ALA A 307
 None
 0.86A 3fpjB-1u0mA:
undetectable		 3fpjB-1u0mA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 VAL A  80
ALA A 164
ILE A 162
ILE A  98
ILE A  84
 None
 1.15A 3hbbD-1u0mA:
undetectable		 3hbbD-1u0mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 7 ARG A 275
LEU A 187
ASN A 303
ALA A 305
ILE A 222
 None
None
None
15P  A1000 ( 4.6A)
None
 1.37A 3spkB-1u0mA:
undetectable		 3spkB-1u0mA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 9 VAL A 163
TYR A 103
ILE A  84
ILE A 192
PHE A 167
 None
 1.50A 4afgA-1u0mA:
0.0
4afgB-1u0mA:
0.0		 4afgA-1u0mA:
20.62
4afgB-1u0mA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 GLY A 141
GLY A 137
GLU A 166
TYR A 224
 None
None
None
15P  A1000 (-4.9A)
 0.93A 4fgzA-1u0mA:
undetectable		 4fgzA-1u0mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 141
ALA A 305
ILE A 162
LEU A 136
VAL A 104
 None
15P  A1000 ( 4.6A)
None
None
None
 1.07A 4uw0A-1u0mA:
undetectable		 4uw0A-1u0mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 284
LEU A 280
GLU A 252
LEU A 250
LEU A 246
 None
 1.07A 4wg0H-1u0mA:
undetectable
4wg0I-1u0mA:
undetectable
4wg0J-1u0mA:
undetectable		 4wg0H-1u0mA:
4.09
4wg0I-1u0mA:
4.09
4wg0J-1u0mA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 246
GLU A 252
LEU A 250
LEU A 284
LEU A 280
 None
 0.81A 4wg0K-1u0mA:
undetectable
4wg0L-1u0mA:
undetectable
4wg0M-1u0mA:
undetectable		 4wg0K-1u0mA:
4.09
4wg0L-1u0mA:
4.09
4wg0M-1u0mA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 141
GLY A 332
THR A 338
ILE A 162
LEU A 136
 None
 1.02A 5bw4A-1u0mA:
undetectable		 5bw4A-1u0mA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 142
GLY A 332
THR A 338
ILE A 162
LEU A 136
 None
 1.14A 5bw4A-1u0mA:
undetectable		 5bw4A-1u0mA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 ILE A 192
GLY A 191
PHE A 231
PHE A 109
 None
 0.90A 5hieD-1u0mA:
undetectable		 5hieD-1u0mA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 190
GLY A 189
ASN A 303
ASN A 185
PHE A 233
 None
None
None
GOL  A2000 ( 2.9A)
15P  A1000 (-4.1A)
 1.28A 5kc4E-1u0mA:
undetectable		 5kc4E-1u0mA:
19.90