SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1u0s CHEMOTAXIS PROTEIN
CHEA
CHEMOTAXIS PROTEIN
CHEY
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 SER Y  82
ALA A 194
PHE Y 101
ILE Y  91
 None
 1.02A 1gm7A-1u0sY:
undetectable
1gm7B-1u0sY:
undetectable		 1gm7A-1u0sY:
22.38
1gm7B-1u0sY:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1u0s CHEMOTAXIS PROTEIN
CHEY
(Thermotoga
maritima) 		5 / 9 VAL Y   5
THR Y  52
MET Y  53
THR Y  34
ALA Y  33
 None
 1.17A 2cojA-1u0sY:
undetectable
2cojB-1u0sY:
undetectable		 2cojA-1u0sY:
13.91
2cojB-1u0sY:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1u0s CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 8 ALA A 245
LEU A 203
ILE A 257
VAL A 233
ILE A 234
 None
 1.24A 2uxpA-1u0sA:
undetectable		 2uxpA-1u0sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u0s CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 VAL A 229
LEU A 203
SER A 193
VAL A 183
THR A 213
 None
 1.07A 4eckB-1u0sA:
undetectable		 4eckB-1u0sA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1u0s CHEMOTAXIS PROTEIN
CHEA
CHEMOTAXIS PROTEIN
CHEY
(Thermotoga
maritima) 		5 / 10 LEU A 198
ILE Y  91
ALA Y  93
ILE Y  94
ILE Y  55
 None
 1.02A 5mvmD-1u0sA:
undetectable
5mvmE-1u0sA:
undetectable		 5mvmD-1u0sA:
19.32
5mvmE-1u0sA:
19.32