SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		5 / 8 ALA A  22
LEU A   9
LEU A  80
ILE A 121
VAL A 128
 None
 1.16A 2uxpA-1u0tA:
undetectable		 2uxpA-1u0tA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A 194
SER A 162
GLU A 164
ASP A 189
 None
 1.32A 3bc9A-1u0tA:
undetectable		 3bc9A-1u0tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 218
PRO A 232
ASP A 189
VAL A 254
 None
 0.98A 3n3iA-1u0tA:
undetectable		 3n3iA-1u0tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		5 / 6 ILE A 264
LEU A 163
GLU A 177
GLU A 244
ALA A 242
 None
 1.35A 3r9sA-1u0tA:
undetectable		 3r9sA-1u0tA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_SAMA1000_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 160
PHE A 112
PRO A 213
ARG A 138
ASN A 159
 None
 1.31A 3smtA-1u0tA:
0.0		 3smtA-1u0tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 189
ALA A 203
TYR A 202
SER A 205
GLY A 207
 None
 1.25A 4mmaA-1u0tA:
undetectable		 4mmaA-1u0tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 280
ARG A 274
VAL A 276
 None
 1.03A 4x3uA-1u0tA:
undetectable
4x3uB-1u0tA:
0.0		 4x3uA-1u0tA:
15.77
4x3uB-1u0tA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 264
GLY A 166
ILE A 245
LEU A 253
 None
 0.88A 5dzki-1u0tA:
undetectable
5dzkj-1u0tA:
undetectable
5dzkx-1u0tA:
undetectable		 5dzki-1u0tA:
23.15
5dzkj-1u0tA:
23.15
5dzkx-1u0tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 241
VAL A 220
PRO A 222
 None
 0.62A 5uunA-1u0tA:
undetectable		 5uunA-1u0tA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		4 / 9 VAL A 128
HIS A 127
LEU A   8
VAL A  11
 None
 0.95A 6c2mD-1u0tA:
undetectable		 6c2mD-1u0tA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 254
GLU A 164
ILE A 264
 None
 0.61A 6f7lB-1u0tA:
undetectable		 6f7lB-1u0tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 141
LEU A 139
ARG A 274
 None
 0.65A 6fgcA-1u0tA:
3.5		 6fgcA-1u0tA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 141
LEU A 139
ARG A 274
 None
 0.66A 6fgdA-1u0tA:
3.4		 6fgdA-1u0tA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A  21
ILE A 121
ALA A 282
LEU A  82
LEU A  78
 None
 1.15A 6ie8A-1u0tA:
0.0		 6ie8A-1u0tA:
22.04