SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 5 HIS A 306
SER A 194
LEU A 108
GLY A 219
 None
 0.94A 1a4lB-1u0uA:
undetectable		 1a4lB-1u0uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 VAL A 385
LEU A 373
VAL A 227
ILE A  21
ILE A  24
 None
 0.92A 1epbA-1u0uA:
undetectable		 1epbA-1u0uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 VAL A 385
LEU A 373
VAL A 227
ILE A  21
ILE A  24
 None
 0.80A 1epbB-1u0uA:
undetectable		 1epbB-1u0uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 ALA A  19
LEU A 174
LEU A 387
SER A 389
ILE A  24
 None
 1.02A 2oipE-1u0uA:
undetectable		 2oipE-1u0uA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 6 THR A 172
VAL A 173
GLU A 195
CYH A 193
 None
 1.25A 3b6rB-1u0uA:
undetectable		 3b6rB-1u0uA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 8 CYH A 285
PHE A 374
THR A 381
ILE A 382
THR A 248
 None
 1.49A 3bpxA-1u0uA:
0.0
3bpxB-1u0uA:
undetectable		 3bpxA-1u0uA:
17.01
3bpxB-1u0uA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 ILE A 242
MET A 286
PHE A 290
LEU A 327
THR A 330
 None
 1.17A 3em0B-1u0uA:
undetectable		 3em0B-1u0uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 8 VAL A 345
VAL A 372
PHE A 374
HIS A 306
 None
 0.99A 3fhxB-1u0uA:
undetectable		 3fhxB-1u0uA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 GLU A 236
PRO A 231
GLY A 121
ILE A 117
GLU A 114
 None
 1.48A 3jb2A-1u0uA:
0.0		 3jb2A-1u0uA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 LEU A 266
GLY A 166
GLY A 375
GLY A 258
LEU A 380
 None
 1.10A 3ku1G-1u0uA:
undetectable		 3ku1G-1u0uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 5 ASP A 314
LEU A 313
ILE A 278
PRO A 275
 None
 1.20A 3s3vA-1u0uA:
undetectable		 3s3vA-1u0uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 5 SER A 389
THR A 363
GLU A 241
ASP A 230
 None
 1.17A 3tm4A-1u0uA:
undetectable		 3tm4A-1u0uA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 5 SER A 389
THR A 363
GLU A 241
ASP A 230
 None
 1.19A 3tm4B-1u0uA:
undetectable		 3tm4B-1u0uA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 7 THR A  46
HIS A  50
ASN A  51
LEU A  54
 None
 1.36A 4awuA-1u0uA:
undetectable		 4awuA-1u0uA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 9 GLY A 309
GLY A 308
PHE A 268
ILE A 257
PHE A 218
 None
 1.12A 4fgjA-1u0uA:
0.0
4fgjB-1u0uA:
0.0		 4fgjA-1u0uA:
21.45
4fgjB-1u0uA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 11 PHE A 268
ILE A 257
PHE A 218
GLY A 309
GLY A 308
 None
 1.16A 4fglA-1u0uA:
undetectable
4fglB-1u0uA:
undetectable		 4fglA-1u0uA:
21.45
4fglB-1u0uA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 GLY A 309
GLY A 308
PHE A 268
ILE A 257
PHE A 218
 None
 1.23A 4zvmA-1u0uA:
undetectable
4zvmB-1u0uA:
undetectable		 4zvmA-1u0uA:
20.10
4zvmB-1u0uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 ALA A 181
ALA A 177
LEU A 174
ALA A  15
SER A  20
 None
 1.43A 5jglB-1u0uA:
undetectable		 5jglB-1u0uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		3 / 3 LYS A 319
LEU A 327
ILE A 312
 None
 0.74A 5kc0A-1u0uA:
undetectable		 5kc0A-1u0uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 ILE A 192
LEU A 130
PHE A 145
VAL A 157
ILE A 127
 None
 0.89A 5mueA-1u0uA:
undetectable		 5mueA-1u0uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 8 ARG A 107
ALA A 109
PHE A 347
GLY A 221
 None
 0.90A 5v0vA-1u0uA:
undetectable		 5v0vA-1u0uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 TRP A 303
THR A 330
LEU A 327
SER A 279
THR A 384
 None
 1.22A 5w8aA-1u0uA:
0.0		 5w8aA-1u0uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		4 / 7 PHE A 376
GLY A 377
GLY A 379
THR A 135
 None
 0.81A 5ybbB-1u0uA:
undetectable		 5ybbB-1u0uA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		3 / 3 GLU A 182
ASP A 230
PRO A 231
 None
 0.49A 6berA-1u0uA:
undetectable		 6berA-1u0uA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 9 LEU A 266
THR A 200
SER A 211
GLY A 214
PHE A 218
 None
 1.32A 6ebpA-1u0uA:
undetectable		 6ebpA-1u0uA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0F-1u0uA:
undetectable		 6ew0F-1u0uA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1u0u DIHYDROPINOSYLVIN
SYNTHASE
(Pinus
sylvestris) 		5 / 12 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0G-1u0uA:
undetectable		 6ew0G-1u0uA:
12.96