SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 12 PHE A  12
TRP A  23
VAL A 109
ALA A 117
ILE A 119
 None
 0.90A 1epbA-1u0xA:
15.0		 1epbA-1u0xA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		3 / 3 ASP A  30
LEU A 123
LEU A 133
 None
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
 0.37A 1ikeA-1u0xA:
35.9		 1ikeA-1u0xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 9 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.38A 1mj2A-1u0xA:
undetectable		 1mj2A-1u0xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 9 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.40A 1mj2C-1u0xA:
undetectable		 1mj2C-1u0xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 9 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.38A 1mjoA-1u0xA:
undetectable		 1mjoA-1u0xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 9 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.40A 1mjoB-1u0xA:
undetectable		 1mjoB-1u0xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 9 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.39A 1mjoC-1u0xA:
undetectable		 1mjoC-1u0xA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		4 / 5 ASP A  30
GLU A  32
LEU A 123
LEU A 133
 None
None
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
 0.79A 1np1A-1u0xA:
32.1		 1np1A-1u0xA:
90.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		3 / 3 ASP A  30
LEU A 123
LEU A 133
 None
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
 0.41A 1np1B-1u0xA:
31.9		 1np1B-1u0xA:
90.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		5 / 5 ASP A  30
GLU A  32
THR A 121
LEU A 123
LEU A 133
 None
None
HEM  A 185 ( 4.3A)
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
 0.91A 1u18B-1u0xA:
31.5		 1u18B-1u0xA:
89.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		4 / 8 THR A 121
VAL A  25
VAL A  36
ASP A  30
 HEM  A 185 ( 4.3A)
None
HEM  A 185 (-3.7A)
None
 1.16A 4l4dA-1u0xA:
0.0		 4l4dA-1u0xA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 1u0x NITROPHORIN 4
(Rhodnius
prolixus) 		4 / 6 LYS A 162
ASP A  27
PRO A  33
LEU A  31
 None
 1.24A 5bmvB-1u0xA:
undetectable		 5bmvB-1u0xA:
20.00