SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 203
VAL A 178
TRP A 242
 None
 1.06A 1c4dA-1u10A:
undetectable
1c4dB-1u10A:
undetectable		 1c4dA-1u10A:
8.18
1c4dB-1u10A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 ILE A  78
LEU A  81
VAL A  85
 None
 0.32A 1mz9B-1u10A:
undetectable		 1mz9B-1u10A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 242
PHE A 204
TRP A 203
 None
 1.27A 1r15C-1u10A:
undetectable		 1r15C-1u10A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 242
PHE A 204
TRP A 203
 None
 1.25A 1r15F-1u10A:
undetectable		 1r15F-1u10A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 242
PHE A 204
TRP A 203
 None
 1.25A 1r15G-1u10A:
undetectable		 1r15G-1u10A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 TRP A 242
PHE A 204
TRP A 203
 None
 1.26A 1r15H-1u10A:
undetectable		 1r15H-1u10A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 109
HIS A 209
ASP A  97
PRO A 138
 None
SO4  A 500 (-4.0A)
None
None
 1.13A 1th6A-1u10A:
undetectable		 1th6A-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 109
HIS A 209
ASP A 120
PRO A 138
 None
SO4  A 500 (-4.0A)
ZN  A 400 (-2.2A)
None
 1.16A 1th6A-1u10A:
undetectable		 1th6A-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 12 SER A 241
TRP A 242
ALA A 237
GLY A 236
PRO A 202
 None
 0.90A 1vpoH-1u10A:
undetectable
1vpoL-1u10A:
undetectable		 1vpoH-1u10A:
20.66
1vpoL-1u10A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 109
HIS A 209
ASP A  97
PRO A 138
 None
SO4  A 500 (-4.0A)
None
None
 1.14A 2armA-1u10A:
undetectable		 2armA-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 7 GLY A 109
HIS A 209
ASP A 120
PRO A 138
 None
SO4  A 500 (-4.0A)
ZN  A 400 (-2.2A)
None
 1.14A 2armA-1u10A:
undetectable		 2armA-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 12 HIS A 113
SER A 112
PHE A  77
ILE A 121
LEU A 117
 ZN  A 400 (-3.2A)
None
None
None
None
 1.13A 3fzgA-1u10A:
undetectable		 3fzgA-1u10A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 5 ILE A  37
PRO A 262
SER A  41
GLY A  43
 None
 1.14A 3tkdA-1u10A:
undetectable		 3tkdA-1u10A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 8 TRP A 203
PHE A 177
HIS A 211
ARG A 213
 None
None
ZN  A 400 (-3.0A)
None
 1.34A 4cx7A-1u10A:
undetectable
4cx7B-1u10A:
undetectable		 4cx7A-1u10A:
20.09
4cx7B-1u10A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 8 SER A  41
SER A 112
GLY A 109
GLY A  99
 None
 0.85A 4fo4B-1u10A:
undetectable		 4fo4B-1u10A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 11 ILE A  78
LEU A 163
ASP A 120
GLY A  96
VAL A 212
 None
None
ZN  A 400 (-2.2A)
None
None
 1.33A 4fogC-1u10A:
0.0		 4fogC-1u10A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		4 / 7 ARG A 213
TRP A 203
PHE A 177
HIS A 211
 None
None
None
ZN  A 400 (-3.0A)
 1.35A 5ad9A-1u10A:
undetectable
5ad9B-1u10A:
undetectable		 5ad9A-1u10A:
20.00
5ad9B-1u10A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 12 ALA A  48
GLY A  32
SER A  33
GLY A 116
LEU A 268
 None
 1.11A 5gwxA-1u10A:
undetectable		 5gwxA-1u10A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 12 PRO A 217
ILE A  45
GLY A  70
ASP A  49
ARG A 215
 None
 0.95A 5h5fA-1u10A:
undetectable		 5h5fA-1u10A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 LEU A 163
LEU A  81
ARG A 175
 None
 0.66A 5hnzB-1u10A:
undetectable		 5hnzB-1u10A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 11 VAL A  93
ILE A 121
ILE A 164
ILE A 176
PHE A  77
 None
 1.11A 5hw8G-1u10A:
undetectable		 5hw8G-1u10A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		5 / 12 GLY A  96
GLY A  99
LEU A 135
ASP A  97
PHE A 122
 None
 1.31A 5yn6A-1u10A:
undetectable		 5yn6A-1u10A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 ASN A  42
PRO A 262
GLN A 266
 None
 0.85A 6jnhA-1u10A:
undetectable		 6jnhA-1u10A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE
(Escherichia
coli) 		3 / 3 ASN A  42
PRO A 262
GLN A 266
 None
 0.86A 6jogA-1u10A:
undetectable		 6jogA-1u10A:
21.24