SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1u27 CYTOHESIN 2
(Mus
musculus) 		5 / 12 TYR A 291
PHE A 282
LEU A 325
LEU A 289
HIS A 351
 4IP  A 101 (-4.6A)
None
None
None
4IP  A 101 (-3.8A)
 1.32A 4j03A-1u27A:
undetectable		 4j03A-1u27A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u27 CYTOHESIN 2
(Mus
musculus) 		4 / 4 LEU A 325
ARG A 355
ILE A 356
PHE A 323
 None
 1.17A 5kirB-1u27A:
undetectable		 5kirB-1u27A:
13.00