SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1u2b CYTOHESIN 3
(Mus
musculus) 		4 / 5 TYR A 296
GLU A 298
PRO A 305
ASP A 302
 SO4  A 501 (-4.8A)
None
None
None
 1.46A 1i7zB-1u2bA:
0.0		 1i7zB-1u2bA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u2b CYTOHESIN 3
(Mus
musculus) 		5 / 12 LEU A 271
LYS A 273
SER A 375
ILE A 376
LEU A 330
 None
SO4  A 501 ( 2.8A)
None
None
None
 1.05A 4ky8A-1u2bA:
undetectable		 4ky8A-1u2bA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u2b CYTOHESIN 3
(Mus
musculus) 		5 / 12 LEU A 271
LYS A 273
SER A 375
ILE A 376
LEU A 330
 None
SO4  A 501 ( 2.8A)
None
None
None
 1.09A 4ky8C-1u2bA:
undetectable		 4ky8C-1u2bA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u2b CYTOHESIN 3
(Mus
musculus) 		5 / 12 LEU A 271
LYS A 273
SER A 375
ILE A 376
LEU A 330
 None
SO4  A 501 ( 2.8A)
None
None
None
 1.06A 4ky8D-1u2bA:
undetectable		 4ky8D-1u2bA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u2b CYTOHESIN 3
(Mus
musculus) 		5 / 12 LEU A 271
LYS A 273
SER A 375
ILE A 376
LEU A 330
 None
SO4  A 501 ( 2.8A)
None
None
None
 1.05A 4ky8E-1u2bA:
undetectable		 4ky8E-1u2bA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1u2b CYTOHESIN 3
(Mus
musculus) 		3 / 3 ARG A 285
GLU A 346
TYR A 296
 SO4  A 501 (-3.9A)
None
SO4  A 501 (-4.8A)
 1.00A 4r29D-1u2bA:
undetectable		 4r29D-1u2bA:
21.83