SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A  29
ARG A  65
LEU A 108
ASP A  87
 None
 1.07A 2qqcB-1u2hA:
undetectable
2qqcC-1u2hA:
undetectable		 2qqcB-1u2hA:
22.22
2qqcC-1u2hA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 108
ASP A  87
GLN A  29
ARG A  65
 None
 1.07A 2qqcA-1u2hA:
undetectable
2qqcF-1u2hA:
undetectable		 2qqcA-1u2hA:
17.17
2qqcF-1u2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 108
ASP A  87
GLN A  29
ARG A  65
 None
 1.00A 2qqcG-1u2hA:
undetectable
2qqcJ-1u2hA:
undetectable		 2qqcG-1u2hA:
17.17
2qqcJ-1u2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 108
ASP A  87
GLN A  29
ARG A  65
 None
 1.05A 2qqcI-1u2hA:
undetectable
2qqcL-1u2hA:
undetectable		 2qqcI-1u2hA:
17.17
2qqcL-1u2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  34
ASP A  36
VAL A  31
VAL A 110
 None
 0.75A 3fi0G-1u2hA:
undetectable		 3fi0G-1u2hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  34
ASP A  36
VAL A  31
VAL A 110
 None
 0.80A 3fi0I-1u2hA:
undetectable		 3fi0I-1u2hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  34
ASP A  36
VAL A  31
VAL A 110
 None
 0.79A 3fi0Q-1u2hA:
undetectable		 3fi0Q-1u2hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A  20
VAL A  43
ILE A  41
VAL A  51
 None
 0.67A 5bmvC-1u2hA:
undetectable		 5bmvC-1u2hA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A  74
GLY A  73
GLU A  70
PHE A  22
ILE A  41
 None
 1.37A 5lbtA-1u2hA:
undetectable
5lbtB-1u2hA:
undetectable		 5lbtA-1u2hA:
21.76
5lbtB-1u2hA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1
(Homo
sapiens) 		3 / 3 ILE A  41
VAL A  43
PRO A  20
 None
 0.70A 5uunA-1u2hA:
undetectable		 5uunA-1u2hA:
16.61