SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		3 / 3 ALA A 713
VAL A 715
TRP A 714
 None
 0.78A 1bdwA-1u2lA:
undetectable
1bdwB-1u2lA:
undetectable		 1bdwA-1u2lA:
4.15
1bdwB-1u2lA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 571
THR A 564
LEU A 492
GLY A 489
PHE A 569
 None
 1.46A 1d4fD-1u2lA:
undetectable		 1d4fD-1u2lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 5 GLY A 578
LEU A 595
THR A 591
VAL A 613
 None
 0.95A 1ekjF-1u2lA:
undetectable
1ekjG-1u2lA:
undetectable		 1ekjF-1u2lA:
22.70
1ekjG-1u2lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 9 LEU A 525
LEU A 453
GLU A 519
ILE A 457
PHE A 552
 None
 1.38A 1gx8A-1u2lA:
undetectable		 1gx8A-1u2lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 GLY A 614
GLY A 615
VAL A 537
LEU A 638
LEU A 619
 None
 0.86A 1mx1D-1u2lA:
undetectable		 1mx1D-1u2lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		3 / 3 ILE A 528
LEU A 531
VAL A 535
 None
 0.34A 1mz9B-1u2lA:
undetectable		 1mz9B-1u2lA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 525
ILE A 516
VAL A 470
LEU A 467
LEU A 462
 None
 1.17A 1s19A-1u2lA:
undetectable		 1s19A-1u2lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 0.93A 2bm9C-1u2lA:
undetectable		 2bm9C-1u2lA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.07A 2bm9D-1u2lA:
undetectable		 2bm9D-1u2lA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.01A 2br4A-1u2lA:
undetectable		 2br4A-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 0.99A 2br4C-1u2lA:
undetectable		 2br4C-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.02A 2br4D-1u2lA:
undetectable		 2br4D-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.00A 2br4E-1u2lA:
undetectable		 2br4E-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.14A 2br4F-1u2lA:
undetectable		 2br4F-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		3 / 3 ALA A 505
GLY A 620
SER A 463
 None
 0.59A 2ivuA-1u2lA:
undetectable		 2ivuA-1u2lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 8 PHE A 642
VAL A 683
LEU A 690
ALA A 694
 None
 0.98A 3ax7A-1u2lA:
undetectable		 3ax7A-1u2lA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 VAL A 618
GLY A 614
ILE A 548
ALA A 540
ALA A 541
 None
 1.00A 3sufB-1u2lA:
undetectable		 3sufB-1u2lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 6 VAL A 468
TRP A 714
PHE A 710
GLU A 538
 None
 1.49A 3ufrA-1u2lA:
undetectable
3ufrB-1u2lA:
1.8		 3ufrA-1u2lA:
21.10
3ufrB-1u2lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 7 PHE A 642
VAL A 683
LEU A 690
ALA A 694
 None
 0.97A 3uniA-1u2lA:
0.0		 3uniA-1u2lA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 8 GLY A 614
GLY A 615
MET A 616
GLY A 620
VAL A 635
 None
 1.20A 3v1nA-1u2lA:
undetectable		 3v1nA-1u2lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 5 LEU A 510
PRO A 511
LEU A 513
ILE A 529
 None
 1.05A 4klrA-1u2lA:
undetectable		 4klrA-1u2lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 8 ASN A 581
TRP A 653
PHE A 663
THR A 610
 None
 1.37A 5hqaA-1u2lA:
undetectable		 5hqaA-1u2lA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		3 / 3 GLY A 481
GLY A 480
GLN A 600
 None
 0.43A 5imsA-1u2lA:
undetectable		 5imsA-1u2lA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		4 / 6 ASP A 577
ASP A 721
ARG A 491
GLN A 497
 None
 1.15A 5l6eA-1u2lA:
undetectable		 5l6eA-1u2lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1u2l PEROXIDASE/CATALASE
HPI
(Escherichia
coli) 		5 / 12 VAL A 512
GLU A 514
ALA A 509
ARG A 498
LEU A 492
 None
 1.20A 5nd4B-1u2lA:
undetectable		 5nd4B-1u2lA:
21.33