SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_5 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	1u2m	HISTONE-LIKE PROTEIN HLP-1 (Escherichia coli)	3 / 3	THR A 153 LEU A 157 VAL A 160	None	0.31A	1mz9E-1u2mA: 1.2	1mz9E-1u2mA: 18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOI_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	1u2m	HISTONE-LIKE PROTEIN HLP-1 (Escherichia coli)	4 / 5	ASP A 151 GLY A 30 VAL A 136 ILE A 26	None	1.00A	2aoiA-1u2mA: undetectable	2aoiA-1u2mA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8G_B_017B401_1 (POL POLYPROTEIN)	1u2m	HISTONE-LIKE PROTEIN HLP-1 (Escherichia coli)	5 / 12	LEU A 157 GLY A 30 ASP A 138 VAL A 124 VAL A 160	None	1.07A	2f8gA-1u2mA: undetectable	2f8gA-1u2mA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXW_B_017B200_1 (HIV-1 PROTEASE)	1u2m	HISTONE-LIKE PROTEIN HLP-1 (Escherichia coli)	5 / 10	LEU A 157 GLY A 30 ASP A 138 VAL A 124 VAL A 160	None	1.02A	3oxwA-1u2mA: undetectable	3oxwA-1u2mA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9K_A_TYLA2200_1 (CREB-BINDING PROTEIN)	1u2m	HISTONE-LIKE PROTEIN HLP-1 (Escherichia coli)	4 / 6	VAL A 27 LEU A 32 ILE A 120 VAL A 127	None	0.93A	4a9kA-1u2mA: 0.2	4a9kA-1u2mA: 24.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_D_VDYD1001_5","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","1u2m","HISTONE-LIKE PROTEIN HLP-1","Escherichia coli",3,"THR A 153;LEU A 157;VAL A 160","None","0.31A","1mz9E-1u2mA:1.2","1mz9E-1u2mA:18.88"],["2AOI_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","1u2m","HISTONE-LIKE PROTEIN HLP-1","Escherichia coli",4,"ASP A 151;GLY A  30;VAL A 136;ILE A  26","None","1.00A","2aoiA-1u2mA:undetectable","2aoiA-1u2mA:16.44"],["2F8G_B_017B401_1","POL POLYPROTEIN;POL POLYPROTEIN","1u2m","HISTONE-LIKE PROTEIN HLP-1","Escherichia coli",5,"LEU A 157;GLY A  30;ASP A 138;VAL A 124;VAL A 160","None","1.07A","2f8gA-1u2mA:undetectable","2f8gA-1u2mA:16.44"],["3OXW_B_017B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","1u2m","HISTONE-LIKE PROTEIN HLP-1","Escherichia coli",5,"LEU A 157;GLY A  30;ASP A 138;VAL A 124;VAL A 160","None","1.02A","3oxwA-1u2mA:undetectable","3oxwA-1u2mA:18.54"],["4A9K_A_TYLA2200_1","CREB-BINDING PROTEIN","1u2m","HISTONE-LIKE PROTEIN HLP-1","Escherichia coli",4,"VAL A  27;LEU A  32;ILE A 120;VAL A 127","None","0.93A","4a9kA-1u2mA:0.2","4a9kA-1u2mA:24.03"]]