SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  29
ALA A  59
VAL A  40
TYR A  67
GLN A  28
 None
 1.45A 1aqbA-1u2qA:
undetectable		 1aqbA-1u2qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A  41
GLU A  79
THR A  78
LEU A  86
 None
 1.39A 1d4fC-1u2qA:
4.6		 1d4fC-1u2qA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 158
VAL A 153
TRP A 152
 None
 0.76A 1kqeA-1u2qA:
undetectable
1kqeE-1u2qA:
undetectable		 1kqeA-1u2qA:
5.98
1kqeE-1u2qA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 158
VAL A 153
TRP A 152
 None
 0.75A 1kqeB-1u2qA:
undetectable
1kqeD-1u2qA:
undetectable		 1kqeB-1u2qA:
5.98
1kqeD-1u2qA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 152
ALA A 158
VAL A 153
 None
 0.76A 1kqeB-1u2qA:
undetectable
1kqeD-1u2qA:
undetectable		 1kqeB-1u2qA:
5.98
1kqeD-1u2qA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 152
ALA A 158
VAL A 153
 None
 0.75A 1kqeA-1u2qA:
undetectable
1kqeE-1u2qA:
undetectable		 1kqeA-1u2qA:
5.98
1kqeE-1u2qA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  77
VAL A  76
LEU A  97
LEU A  86
ALA A  43
 None
 1.27A 1pbcA-1u2qA:
3.6		 1pbcA-1u2qA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 114
ARG A 116
ASP A 151
 None
 0.80A 4fp9A-1u2qA:
undetectable		 4fp9A-1u2qA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 149
LEU A  34
LEU A  29
LEU A  85
PHE A  25
 None
 1.03A 4odoA-1u2qA:
undetectable		 4odoA-1u2qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 149
LEU A  34
LEU A  29
LEU A  85
PHE A  25
 None
 1.05A 4odoB-1u2qA:
undetectable		 4odoB-1u2qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 149
LEU A  34
LEU A  29
LEU A  85
PHE A  25
 None
 1.03A 4odoC-1u2qA:
undetectable		 4odoC-1u2qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 0.99A 5ewuA-1u2qA:
undetectable		 5ewuA-1u2qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 1.03A 5ewuB-1u2qA:
undetectable		 5ewuB-1u2qA:
19.06