SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 TRP A 153
ARG A 374
THR A 154
 None
ADP  A1001 (-3.3A)
None
 0.56A 1df7A-1u2vA:
undetectable		 1df7A-1u2vA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 11 LEU A 139
VAL A 136
ILE A  97
GLU A 132
VAL A  10
 None
 1.19A 1gx9A-1u2vA:
undetectable		 1gx9A-1u2vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 GLU A 280
HIS A 284
ASP A 237
 None
 0.85A 1i9gA-1u2vA:
undetectable		 1i9gA-1u2vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		3 / 3 GLU B 257
LYS B 253
VAL B 254
 None
 0.88A 1l2iA-1u2vB:
undetectable		 1l2iA-1u2vB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 8 ILE A 195
ILE A 296
GLU A 298
VAL A 299
ILE A 193
 None
 1.28A 1linA-1u2vA:
undetectable		 1linA-1u2vA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1u2v ACTIN-RELATED
PROTEIN 2
ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		4 / 6 TYR A 184
GLU A 389
ILE A 141
GLY B 201
 None
 1.10A 1maaB-1u2vA:
undetectable
1maaD-1u2vA:
undetectable		 1maaB-1u2vA:
20.07
1maaD-1u2vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 10 THR A 326
VAL A 367
THR A 166
VAL A 177
VAL A 300
 None
 1.40A 1o76A-1u2vA:
undetectable		 1o76A-1u2vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 8 VAL F  30
TYR B 225
ASP G  17
ASP G  15
 None
 1.25A 1pk2A-1u2vF:
undetectable		 1pk2A-1u2vF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		5 / 12 GLY B 256
GLY B 255
GLU B 257
LEU B 196
PHE B 259
 None
 1.12A 1qzzA-1u2vB:
undetectable		 1qzzA-1u2vB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 12 LEU D 116
ALA D 122
GLU D 126
LEU D  84
ILE D  59
 None
 1.15A 1s9pA-1u2vD:
undetectable		 1s9pA-1u2vD:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 7 ASN A 135
ARG D 248
HIS D 252
VAL D 175
 None
 1.20A 1wu8A-1u2vA:
undetectable
1wu8C-1u2vA:
undetectable		 1wu8A-1u2vA:
22.79
1wu8C-1u2vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 8 PHE G  11
ARG G  12
ALA B 279
LEU B 182
 None
 1.12A 1x8vA-1u2vG:
undetectable		 1x8vA-1u2vG:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		5 / 12 GLY B 256
GLY B 255
GLU B 257
LEU B 196
PHE B 259
 None
 1.12A 1xdsB-1u2vB:
undetectable		 1xdsB-1u2vB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 12 HIS D 263
THR A 126
ILE A 129
MET A 130
PHE A 134
 None
 1.27A 1xomB-1u2vD:
undetectable		 1xomB-1u2vD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 12 PHE D 165
ASP D 249
ASP D  39
TYR D 146
PHE D 125
 None
 1.18A 1zz1B-1u2vD:
undetectable
1zz1C-1u2vD:
undetectable		 1zz1B-1u2vD:
22.98
1zz1C-1u2vD:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 SER A 297
GLU A 280
ASP A 237
 None
 0.63A 2avdB-1u2vA:
undetectable		 2avdB-1u2vA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 LYS A 225
ASP A  64
CYH A  34
 ADP  A1001 (-3.4A)
None
None
 1.48A 2br4F-1u2vA:
undetectable		 2br4F-1u2vA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 8 GLY G  49
THR G  52
ALA G  53
ALA G  54
 None
 0.49A 2ej3A-1u2vG:
undetectable		 2ej3A-1u2vG:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 8 GLY G  49
THR G  52
ALA G  53
ALA G  54
 None
 0.50A 2ej3C-1u2vG:
undetectable		 2ej3C-1u2vG:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 7 GLY D 188
GLY D 178
PHE D 247
PHE D 225
 None
 0.89A 2qwxA-1u2vD:
undetectable
2qwxB-1u2vD:
undetectable		 2qwxA-1u2vD:
21.29
2qwxB-1u2vD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 12 LEU D 207
ILE D 223
LEU D 251
MET D 182
PHE D 200
 None
 1.10A 2ygnA-1u2vD:
0.0		 2ygnA-1u2vD:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		5 / 12 ILE G 110
SER G 116
GLY G  76
ASP G  73
LEU G 105
 None
 1.25A 2zw9A-1u2vG:
undetectable		 2zw9A-1u2vG:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 11 LEU A 101
ALA A   7
PHE A 390
ALA A 385
PHE A 110
 None
 1.16A 3bszF-1u2vA:
0.0		 3bszF-1u2vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus;
Bos
taurus) 		3 / 3 ARG F 156
GLU F 145
ASP D 272
 None
 0.62A 3g2oA-1u2vF:
undetectable		 3g2oA-1u2vF:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 8 THR B 164
GLY B 277
ALA B 279
ILE B 344
 None
 0.83A 3jusB-1u2vB:
undetectable		 3jusB-1u2vB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_A_CLYA900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 10 GLU A 104
HIS D 252
PHE D 247
ILE D 244
MET D 152
 None
 1.49A 3jz0A-1u2vA:
0.0		 3jz0A-1u2vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL G  82
LEU G  83
LEU G  46
SER G 121
GLY G  76
 None
 1.14A 3kk6A-1u2vG:
undetectable		 3kk6A-1u2vG:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL G  82
LEU G  83
LEU G  46
SER G 121
GLY G  76
 None
 1.13A 3kk6B-1u2vG:
undetectable		 3kk6B-1u2vG:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 8 PHE D 247
PHE F 164
GLY D 178
PHE F 168
 None
 1.08A 3ko0B-1u2vD:
undetectable
3ko0J-1u2vD:
0.8		 3ko0B-1u2vD:
16.55
3ko0J-1u2vD:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 7 PHE D 247
PHE F 164
GLY D 178
PHE F 168
 None
 1.09A 3ko0K-1u2vD:
0.7
3ko0S-1u2vD:
0.8		 3ko0K-1u2vD:
16.55
3ko0S-1u2vD:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 10 ILE A 168
THR A 326
THR A 175
VAL A 177
ILE A 178
 None
 1.34A 3kpbD-1u2vA:
undetectable		 3kpbD-1u2vA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 7 VAL B 155
VAL B 278
ILE B 344
ARG B 294
 None
 1.19A 3ms9B-1u2vB:
undetectable		 3ms9B-1u2vB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 5 ARG F  92
ASP D 171
ASP D 173
ASP D 172
 None
 1.15A 3naiA-1u2vF:
undetectable		 3naiA-1u2vF:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1u2v ACTIN-RELATED
PROTEIN 2
ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 9 LEU B 197
TYR B 202
VAL A 303
ILE A 186
LEU B 246
 None
 1.49A 3oxzA-1u2vB:
undetectable		 3oxzA-1u2vB:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL F  12
TYR F   8
ILE F 118
ILE F  74
TYR F 112
 None
 1.48A 3q5pA-1u2vF:
1.9		 3q5pA-1u2vF:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 8 ALA D 113
LEU D  15
TYR D  97
SER D 108
 None
 0.96A 3qj7A-1u2vD:
undetectable
3qj7D-1u2vD:
undetectable		 3qj7A-1u2vD:
18.33
3qj7D-1u2vD:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 4 LYS G  93
GLN G 127
ILE G 110
LEU G  59
 None
 1.36A 3qt0A-1u2vG:
undetectable		 3qt0A-1u2vG:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 4 GLY B 306
GLY B 160
THR B 164
LEU B 265
 ADP  B1002 (-3.2A)
ADP  B1002 (-3.4A)
None
None
 0.90A 3si7C-1u2vB:
undetectable
3si7D-1u2vB:
undetectable		 3si7C-1u2vB:
23.92
3si7D-1u2vB:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 7 PRO B 262
LEU B 317
GLY B 224
GLU B 263
 None
 0.91A 3tehB-1u2vB:
undetectable		 3tehB-1u2vB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		4 / 6 ILE A 281
PHE A 283
HIS A 176
VAL A 303
 None
 1.21A 4a97I-1u2vA:
undetectable		 4a97I-1u2vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 8 CYH D 120
TYR D  80
ILE D  11
ILE D  59
 None
 0.94A 4afgD-1u2vD:
0.0
4afgE-1u2vD:
0.0		 4afgD-1u2vD:
21.79
4afgE-1u2vD:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 HIS D  44
GLU D  88
SER D  94
PRO D  48
 None
 1.39A 4apjA-1u2vD:
undetectable
4apjP-1u2vD:
undetectable		 4apjA-1u2vD:
20.91
4apjP-1u2vD:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 ASN D 242
LEU D 227
PHE D 121
 None
 0.73A 4dajB-1u2vD:
undetectable		 4dajB-1u2vD:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 8 TYR F   8
LEU F  16
VAL F  72
VAL F  61
 None
 0.79A 4em2A-1u2vF:
0.9		 4em2A-1u2vF:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus;
Bos
taurus) 		4 / 8 ASN A  24
VAL D  31
HIS D  44
ILE D  45
 None
 0.87A 4eyzA-1u2vA:
undetectable		 4eyzA-1u2vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus;
Bos
taurus) 		4 / 8 ASN A  24
VAL D  31
HIS D  44
ILE D  45
 None
 0.87A 4eyzB-1u2vA:
undetectable		 4eyzB-1u2vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 7 GLY B 255
VAL B 241
ILE B 252
PHE B 204
 None
 0.92A 4fglC-1u2vB:
undetectable		 4fglC-1u2vB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 LYS A 254
TYR A 231
ARG A 275
 None
 1.26A 4gc9A-1u2vA:
undetectable		 4gc9A-1u2vA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL D 110
ALA D  23
GLU D  20
PHE D  19
LEU D  17
 None
 0.73A 4i1rA-1u2vD:
undetectable		 4i1rA-1u2vD:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 ARG A  91
GLU A  90
PHE A 134
 None
 0.85A 4kszA-1u2vA:
0.9		 4kszA-1u2vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 6 VAL F  51
VAL G 144
ILE G 141
LEU F  16
 None
 0.96A 4l1wB-1u2vF:
undetectable		 4l1wB-1u2vF:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1u2v ACTIN-RELATED
PROTEIN 2
(Bos
taurus) 		4 / 5 VAL B 278
LEU B 313
VAL B 223
PHE B 266
 None
 0.77A 4lb0B-1u2vB:
undetectable		 4lb0B-1u2vB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 8 ALA F  19
VAL F  51
VAL F  61
ILE F  63
 None
 0.71A 4ll3A-1u2vF:
undetectable		 4ll3A-1u2vF:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 ALA D  16
GLN A  28
GLY A  20
 None
 0.54A 4odoC-1u2vD:
undetectable		 4odoC-1u2vD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 12 PHE A 283
PRO A 285
PHE A 331
SER A 170
GLY A 197
 None
None
None
None
ADP  A1001 (-3.2A)
 1.22A 4olfA-1u2vA:
undetectable		 4olfA-1u2vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		4 / 6 GLN A 336
THR A 154
HIS A 370
ASN A 318
 None
 1.39A 4pfjB-1u2vA:
undetectable		 4pfjB-1u2vA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		5 / 11 GLN B 267
GLU B 263
HIS F  33
GLY B 312
SER B 315
 None
 1.38A 4rv6A-1u2vB:
undetectable		 4rv6A-1u2vB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		5 / 11 GLN B 267
GLU B 263
HIS F  33
GLY B 312
SER B 315
 None
 1.38A 4rv6B-1u2vB:
undetectable		 4rv6B-1u2vB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 5 ILE A  97
PHE D 181
HIS A 108
ASP D 249
 None
 1.39A 4rzvB-1u2vA:
undetectable		 4rzvB-1u2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 GLU D 150
PHE D 165
PHE D 247
HIS D 252
 None
 1.37A 4uciA-1u2vD:
0.0		 4uciA-1u2vD:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 7 GLU D 150
PHE D 165
PHE D 247
HIS D 252
 None
 1.43A 4uciB-1u2vD:
0.0		 4uciB-1u2vD:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 5 ALA F  11
THR F  15
VAL G 144
ILE G 141
 None
 0.88A 4xe3A-1u2vF:
undetectable		 4xe3A-1u2vF:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		4 / 5 LEU G 125
ALA F  11
THR F  15
ILE G 141
 None
 0.86A 4xe3A-1u2vG:
undetectable		 4xe3A-1u2vG:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus) 		5 / 5 LEU G 125
ALA F  11
THR F  15
VAL G 144
ILE G 141
 None
 1.00A 4xe3B-1u2vG:
undetectable		 4xe3B-1u2vG:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 ARG D 118
ARG D 237
ASP D 238
VAL D 124
 None
 0.78A 4xqeA-1u2vD:
undetectable		 4xqeA-1u2vD:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 ARG D 118
ARG D 237
ASP D 238
VAL D 124
 None
 0.81A 4xqeB-1u2vD:
undetectable		 4xqeB-1u2vD:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 8 ARG D 118
ARG D 237
ASP D 238
VAL D 124
 None
 0.80A 4xqgA-1u2vD:
undetectable		 4xqgA-1u2vD:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 8 ARG D 118
ARG D 237
ASP D 238
VAL D 124
 None
 0.80A 4xqgB-1u2vD:
undetectable		 4xqgB-1u2vD:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 12 LEU A 139
VAL A 136
ILE A  97
GLU A 132
VAL A  10
 None
 1.14A 4y0qA-1u2vA:
undetectable		 4y0qA-1u2vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 12 PHE A 283
PRO A 285
PHE A 331
SER A 170
GLY A 197
 None
None
None
None
ADP  A1001 (-3.2A)
 1.24A 4ydqA-1u2vA:
undetectable		 4ydqA-1u2vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 6 PHE G  11
LYS G   9
ASN B 226
ARG B 328
 None
 1.38A 4yv5B-1u2vG:
undetectable		 4yv5B-1u2vG:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 6 PHE G  11
LYS G   9
ASN B 226
ARG B 328
 None
 1.35A 4yv5A-1u2vG:
undetectable		 4yv5A-1u2vG:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1u2v ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2
(Bos
taurus;
Bos
taurus) 		4 / 6 TYR A 184
HIS A 410
GLY B 201
ARG A 123
 None
 1.33A 4zbqA-1u2vA:
undetectable		 4zbqA-1u2vA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		5 / 12 SER A 133
ILE F 142
PHE D 273
GLU A 132
GLU A 128
 None
 1.34A 4zjqD-1u2vA:
0.0		 4zjqD-1u2vA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 10 GLY A 171
GLY A 197
LYS A 228
GLY A 324
SER A 325
 ADP  A1001 (-4.0A)
ADP  A1001 (-3.2A)
ADP  A1001 (-3.3A)
ADP  A1001 (-3.3A)
ADP  A1001 (-4.2A)
 1.01A 5aqfA-1u2vA:
22.7		 5aqfA-1u2vA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 10 GLY A 171
GLY A 197
LYS A 228
GLY A 324
SER A 325
 ADP  A1001 (-4.0A)
ADP  A1001 (-3.2A)
ADP  A1001 (-3.3A)
ADP  A1001 (-3.3A)
ADP  A1001 (-4.2A)
 1.01A 5aqfC-1u2vA:
22.8		 5aqfC-1u2vA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 10 GLY A 171
GLY A 197
LYS A 228
GLY A 324
SER A 325
 ADP  A1001 (-4.0A)
ADP  A1001 (-3.2A)
ADP  A1001 (-3.3A)
ADP  A1001 (-3.3A)
ADP  A1001 (-4.2A)
 0.98A 5aqyA-1u2vA:
22.9		 5aqyA-1u2vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 LYS A  99
ASP D  37
TYR A 100
LEU A  19
 None
 1.34A 5bmvB-1u2vA:
undetectable		 5bmvB-1u2vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		4 / 6 SER A 170
ASP A 338
ARG A 334
GLY A 332
 None
 0.90A 5cdnR-1u2vA:
0.0
5cdnS-1u2vA:
3.0		 5cdnR-1u2vA:
22.02
5cdnS-1u2vA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 ASN D 242
LEU D 227
PHE D 121
 None
 0.75A 5dsgA-1u2vD:
undetectable		 5dsgA-1u2vD:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 THR D 246
ASP D  39
GLU D 150
 None
 0.84A 5fa8A-1u2vD:
undetectable		 5fa8A-1u2vD:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 8 ILE A 186
VAL A 180
ILE A 296
ILE A 193
ASP A 169
 None
 1.49A 5hi2A-1u2vA:
undetectable		 5hi2A-1u2vA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL G 151
LEU G  98
LEU G 106
LEU G  55
PRO G  37
 None
 1.12A 5hnwB-1u2vG:
undetectable		 5hnwB-1u2vG:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		5 / 12 VAL G 151
LEU G  98
LEU G 106
LEU G  55
PRO G  37
 None
 1.19A 5hnyB-1u2vG:
undetectable		 5hnyB-1u2vG:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 6 ARG D 248
ASP A 107
GLY D  40
ASP D  39
 None
 1.21A 5hp1A-1u2vD:
3.7		 5hp1A-1u2vD:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 ARG F  97
HIS D 263
ARG D 267
 None
 0.97A 5iaoC-1u2vF:
undetectable		 5iaoC-1u2vF:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1u2v ARP2/3 COMPLEX 20KDA
SUBUNIT
ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		3 / 3 ARG F  97
HIS D 263
ARG D 267
 None
 0.98A 5iaoF-1u2vF:
undetectable		 5iaoF-1u2vF:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		3 / 3 GLN A 144
THR A 113
ASP A  11
 CA  A 500 ( 4.4A)
None
CA  A 500 (-3.2A)
 0.79A 5k9dA-1u2vA:
undetectable		 5k9dA-1u2vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
(Bos
taurus) 		4 / 8 HIS G 129
GLY G 136
VAL G 138
SER G 140
 None
 0.94A 5m8rC-1u2vG:
undetectable		 5m8rC-1u2vG:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1u2v ACTIN-RELATED
PROTEIN 3
(Bos
taurus) 		5 / 6 VAL A  10
THR A 113
LEU A 101
LEU A   5
GLU A 106
 None
 1.33A 5tudD-1u2vA:
undetectable		 5tudD-1u2vA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
(Bos
taurus) 		4 / 5 PHE D 125
VAL D  41
MET D 152
VAL D 124
 None
 1.16A 6ekzA-1u2vD:
undetectable		 6ekzA-1u2vD:
14.68