SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 356
GLY A 341
ILE A 344
VAL A 306
ILE A 308
 None
 0.94A 1ohrB-1u2xA:
undetectable		 1ohrB-1u2xA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A  35
ASN A  37
ILE A 122
GLY A 117
 SO4  A1003 (-3.8A)
SO4  A1003 ( 4.6A)
None
None
 1.08A 1oniA-1u2xA:
undetectable
1oniB-1u2xA:
undetectable		 1oniA-1u2xA:
16.56
1oniB-1u2xA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 354
VAL A 306
GLY A 307
ILE A 296
 None
 0.69A 1p2yA-1u2xA:
undetectable		 1p2yA-1u2xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 317
GLY A 342
LEU A 354
TYR A 361
ILE A 339
 None
 1.20A 1sq5A-1u2xA:
0.1		 1sq5A-1u2xA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 317
GLY A 342
LEU A 354
TYR A 361
ILE A 339
 None
 1.21A 1sq5B-1u2xA:
0.1		 1sq5B-1u2xA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 317
GLY A 342
LEU A 354
TYR A 361
ILE A 339
 None
 1.21A 1sq5C-1u2xA:
0.2		 1sq5C-1u2xA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		6 / 10 VAL A 356
LEU A 317
GLY A 342
LEU A 354
TYR A 361
ILE A 339
 None
 1.18A 1sq5D-1u2xA:
0.0		 1sq5D-1u2xA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		6 / 10 GLY A 460
ALA A 459
ASP A 455
ILE A 122
ILE A 397
VAL A 135
 None
 1.40A 1t3rA-1u2xA:
undetectable		 1t3rA-1u2xA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 373
PHE A 468
ARG A 471
GLU A 375
 None
 1.13A 2c8aA-1u2xA:
undetectable		 2c8aA-1u2xA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 373
PHE A 468
ARG A 471
GLU A 375
 None
 1.09A 2c8aC-1u2xA:
undetectable		 2c8aC-1u2xA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 282
ALA A  33
ASN A  35
ALA A 120
 None
None
SO4  A1003 (-3.8A)
None
 1.05A 2ejfA-1u2xA:
2.9		 2ejfA-1u2xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  39
THR A 139
PRO A 140
 None
 0.71A 2pynB-1u2xA:
undetectable		 2pynB-1u2xA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  39
THR A 139
PRO A 140
 None
 0.69A 2qakB-1u2xA:
undetectable		 2qakB-1u2xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A 201
PRO A 203
ILE A 202
GLY A 190
 None
 1.17A 2qeuA-1u2xA:
0.8
2qeuC-1u2xA:
undetectable		 2qeuA-1u2xA:
14.01
2qeuC-1u2xA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  52
ILE A  76
ALA A  80
GLY A 196
LEU A 195
 None
 1.06A 2v0mB-1u2xA:
0.5		 2v0mB-1u2xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 305
THR A 126
ILE A 353
GLY A 454
 None
 0.98A 2v0mB-1u2xA:
undetectable		 2v0mB-1u2xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 340
ARG A 430
ILE A 339
 None
 0.64A 2xn5B-1u2xA:
undetectable		 2xn5B-1u2xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 341
LEU A 340
ASP A 347
LEU A 317
LEU A 320
 None
 0.99A 2yqzA-1u2xA:
4.6		 2yqzA-1u2xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 341
LEU A 340
ASP A 347
LEU A 317
LEU A 320
 None
 0.96A 2yqzB-1u2xA:
4.7		 2yqzB-1u2xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 282
ALA A  33
ASN A  35
ALA A 120
 None
None
SO4  A1003 (-3.8A)
None
 1.04A 2zgwA-1u2xA:
4.6		 2zgwA-1u2xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A 282
ALA A  33
ASN A  35
ALA A 120
 None
None
SO4  A1003 (-3.8A)
None
 1.07A 2zgwB-1u2xA:
4.7		 2zgwB-1u2xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 5 VAL A  94
GLN A 287
PHE A 214
ARG A  81
 None
 1.44A 3bjwE-1u2xA:
0.0		 3bjwE-1u2xA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 122
ALA A 120
LEU A 127
ALA A 128
LEU A 387
 None
 1.13A 3dauA-1u2xA:
undetectable		 3dauA-1u2xA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 202
THR A  48
PHE A 109
PHE A 185
 None
 1.25A 3em0A-1u2xA:
undetectable		 3em0A-1u2xA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 9 GLN A 315
VAL A 286
ILE A 299
VAL A 281
VAL A 306
 None
 1.50A 3fi0J-1u2xA:
undetectable		 3fi0J-1u2xA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 455
ASN A 182
ASP A  39
ILE A 122
GLY A 121
 None
 1.41A 3myuA-1u2xA:
0.3		 3myuA-1u2xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 156
ILE A 123
ALA A  33
THR A  32
ILE A  30
 None
 1.20A 3ndiA-1u2xA:
3.5		 3ndiA-1u2xA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 377
ALA A 461
GLY A 307
VAL A 437
LEU A 381
 None
 1.03A 3ogpB-1u2xA:
undetectable		 3ogpB-1u2xA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_A_CU9A301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 434
VAL A 356
MET A 363
ILE A 365
TYR A 322
 None
 1.38A 3peoA-1u2xA:
0.0
3peoE-1u2xA:
0.0		 3peoA-1u2xA:
17.30
3peoE-1u2xA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 345
GLY A 341
VAL A 306
SER A 458
 None
 0.92A 4acbB-1u2xA:
4.9
4acbC-1u2xA:
4.5		 4acbB-1u2xA:
24.86
4acbC-1u2xA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 ASN A  37
ASP A  39
ASN A 182
 SO4  A1003 ( 4.6A)
None
None
 0.68A 4agaA-1u2xA:
undetectable		 4agaA-1u2xA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 281
VAL A 303
ILE A 269
LEU A 248
LEU A 262
 None
 1.13A 4jtqA-1u2xA:
undetectable		 4jtqA-1u2xA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		6 / 11 GLY A 460
ALA A 459
ASP A 455
ILE A 122
ILE A 397
VAL A 135
 None
 1.37A 4q1xA-1u2xA:
undetectable		 4q1xA-1u2xA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A 356
GLY A 341
ILE A 344
VAL A 306
ILE A 308
 None
 0.98A 4qgiB-1u2xA:
undetectable		 4qgiB-1u2xA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A 213
PHE A 283
ARG A 292
ILE A 295
 None
 1.34A 5a06B-1u2xA:
4.2		 5a06B-1u2xA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 129
ILE A  24
ILE A 122
ASN A 125
LEU A 394
 None
 1.13A 5fa8A-1u2xA:
undetectable		 5fa8A-1u2xA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 451
LEU A 449
ILE A 169
ILE A 122
LEU A 146
 None
 1.18A 5hbsA-1u2xA:
undetectable		 5hbsA-1u2xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		4 / 5 PHE A 242
GLY A 234
ASP A 268
ILE A 269
 None
 1.00A 5ik1A-1u2xA:
0.0		 5ik1A-1u2xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 378
LEU A 381
GLY A 384
ILE A 345
LEU A 317
 None
 1.25A 5oy01-1u2xA:
undetectable
5oy07-1u2xA:
undetectable		 5oy01-1u2xA:
12.29
5oy07-1u2xA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 10 PHE A 383
ALA A 390
LEU A 387
GLY A 384
LEU A 155
 None
 1.07A 5oy01-1u2xA:
undetectable
5oy07-1u2xA:
undetectable		 5oy01-1u2xA:
12.29
5oy07-1u2xA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 244
ASP A 455
GLY A 117
ASN A  37
ILE A 122
 None
None
None
SO4  A1003 ( 4.6A)
None
 0.81A 5vopA-1u2xA:
2.8		 5vopA-1u2xA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 244
ASP A 455
GLY A 117
ASN A  37
ILE A 122
 None
None
None
SO4  A1003 ( 4.6A)
None
 0.85A 5vopB-1u2xA:
2.9		 5vopB-1u2xA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A 118
ASP A 455
ILE A 241
 SO4  A1003 (-3.4A)
None
None
 0.57A 6dgxB-1u2xA:
undetectable		 6dgxB-1u2xA:
11.34