SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 6 ALA A  59
LYS A 191
ASP A 195
ALA A 196
LEU A  35
 NDP  A 300 (-3.5A)
None
None
None
None
 1.31A 1iwhA-1u31A:
undetectable		 1iwhA-1u31A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LYS A 191
LYS A 192
ASP A 195
ALA A 196
 None
 0.44A 1iwhA-1u31A:
undetectable		 1iwhA-1u31A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 130
TYR A 179
SER A 135
 NDP  A 300 (-4.3A)
None
None
 0.89A 2gvcB-1u31A:
3.2		 2gvcB-1u31A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 130
TYR A 179
SER A 135
 NDP  A 300 (-4.3A)
None
None
 0.88A 2gvcE-1u31A:
2.8		 2gvcE-1u31A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A  89
GLY A  92
PRO A  52
GLY A 128
 NDP  A 300 (-3.1A)
None
None
NDP  A 300 (-3.6A)
 0.95A 2y6rB-1u31A:
3.0		 2y6rB-1u31A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 202
ASP A  67
ILE A  65
GLN A  62
 None
 1.33A 2ya7C-1u31A:
undetectable		 2ya7C-1u31A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A  92
ILE A  83
ALA A  87
PHE A  81
 None
None
NDP  A 300 (-4.9A)
None
 0.96A 3aodA-1u31A:
undetectable		 3aodA-1u31A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A  65
ILE A  83
ILE A 107
VAL A 103
VAL A 108
 None
 0.91A 3kw4A-1u31A:
undetectable		 3kw4A-1u31A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 118
PHE A  81
GLY A 128
LEU A  56
VAL A  69
 None
None
NDP  A 300 (-3.6A)
None
None
 1.22A 4wnwA-1u31A:
undetectable		 4wnwA-1u31A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 118
ILE A  65
THR A 132
ALA A 129
LEU A  56
 None
None
NDP  A 300 (-2.6A)
NDP  A 300 (-3.5A)
None
 1.36A 5ienA-1u31A:
undetectable		 5ienA-1u31A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 128
GLY A  53
LEU A 197
ILE A  50
LEU A 125
 NDP  A 300 (-3.6A)
NDP  A 300 ( 3.7A)
None
None
None
 0.95A 5vm8B-1u31A:
undetectable		 5vm8B-1u31A:
22.22