SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 7 LEU A 101
GLY A  67
ILE A  66
VAL A  21
ILE A 103
 None
 1.15A 2aojB-1u3bA:
undetectable		 2aojB-1u3bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A 101
GLY A  67
ILE A  66
VAL A  21
ILE A 103
 None
 1.08A 2avoA-1u3bA:
undetectable		 2avoA-1u3bA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 8 LEU A  93
VAL A  33
LEU A  31
ILE A  35
LEU A 101
 None
 1.25A 3kp6A-1u3bA:
undetectable
3kp6B-1u3bA:
undetectable		 3kp6A-1u3bA:
23.81
3kp6B-1u3bA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  78
ASP A  68
GLY A  32
ILE A  30
ILE A  70
 None
 1.05A 3nu3A-1u3bA:
undetectable		 3nu3A-1u3bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 201
LEU A  81
LEU A  93
GLY A  92
ILE A  73
 None
 1.02A 3uwlB-1u3bA:
undetectable		 3uwlB-1u3bA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 8 GLY A 138
GLY A 139
MET A 136
ILE A 114
VAL A 146
 None
 1.12A 3v1nA-1u3bA:
undetectable		 3v1nA-1u3bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 12 ILE A 201
LEU A  81
LEU A  93
GLY A  92
ILE A  73
 None
 1.08A 5j7wD-1u3bA:
undetectable		 5j7wD-1u3bA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1
(Homo
sapiens) 		5 / 8 VAL A  21
LEU A  64
ILE A  49
ILE A  35
SER A  77
 None
 1.40A 5numA-1u3bA:
undetectable		 5numA-1u3bA:
17.71