SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 11 CYH A  46
HIS A  67
LEU A 141
CYH A 174
VAL A 294
ILE A 318
 ZN  A 376 (-2.2A)
ZN  A 376 ( 3.3A)
CCB  A1378 ( 4.8A)
ZN  A 376 (-2.2A)
NAD  A1377 ( 3.9A)
CCB  A1378 ( 4.0A)
 0.31A 1ee2A-1u3tA:
65.3		 1ee2A-1u3tA:
87.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 11 CYH A  46
HIS A  67
LEU A 141
CYH A 174
VAL A 294
ILE A 318
 ZN  A 376 (-2.2A)
ZN  A 376 ( 3.3A)
CCB  A1378 ( 4.8A)
ZN  A 376 (-2.2A)
NAD  A1377 ( 3.9A)
CCB  A1378 ( 4.0A)
 0.29A 1ee2B-1u3tA:
65.2		 1ee2B-1u3tA:
87.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 ALA A 156
VAL A  36
ILE A  90
THR A 150
VAL A 152
 None
 0.97A 1k6cB-1u3tA:
undetectable		 1k6cB-1u3tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 12 GLY A  71
ALA A  70
VAL A 169
PRO A 329
VAL A 328
ILE A  90
 None
 1.43A 2f8gB-1u3tA:
undetectable		 2f8gB-1u3tA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 12 GLY A  71
ALA A  70
VAL A 169
PRO A 329
VAL A 328
ILE A  90
 None
 1.43A 2ienA-1u3tA:
undetectable		 2ienA-1u3tA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 12 LEU A 141
GLY A 173
VAL A 152
ILE A  38
VAL A  43
ILE A 143
 CCB  A1378 ( 4.8A)
None
None
None
None
None
 1.25A 2o4lB-1u3tA:
undetectable		 2o4lB-1u3tA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 LEU A 345
ILE A 172
SER A 177
GLY A 179
 None
 0.95A 2otfA-1u3tA:
undetectable		 2otfA-1u3tA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 LYS A 233
ALA A 221
PHE A 198
GLY A 199
 None
None
None
NAD  A1377 (-3.5A)
 1.00A 2rddA-1u3tA:
0.0		 2rddA-1u3tA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 179
GLY A 199
GLY A 201
SER A 206
ILE A 269
 None
NAD  A1377 (-3.5A)
NAD  A1377 (-3.4A)
None
NAD  A1377 (-3.7A)
 0.72A 2wa2A-1u3tA:
4.4		 2wa2A-1u3tA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 GLU A  35
HIS A  34
VAL A  80
ALA A 156
 None
 0.94A 3kp6B-1u3tA:
undetectable		 3kp6B-1u3tA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		6 / 12 GLY A  71
ALA A  70
VAL A 169
PRO A 329
VAL A 328
ILE A  90
 None
 1.50A 3lzuB-1u3tA:
undetectable		 3lzuB-1u3tA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 MET A 276
ARG A 271
GLY A 270
PRO A 295
 None
NAD  A1377 ( 4.7A)
NAD  A1377 ( 3.8A)
None
 1.37A 3ucbB-1u3tA:
undetectable		 3ucbB-1u3tA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.90A 4jq1B-1u3tA:
undetectable		 4jq1B-1u3tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.80A 4l1wB-1u3tA:
undetectable		 4l1wB-1u3tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 8 ALA A  70
VAL A 169
PRO A 329
VAL A 328
ILE A  90
 None
 1.21A 4ll3A-1u3tA:
undetectable		 4ll3A-1u3tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 ALA A  70
VAL A 169
PRO A 329
VAL A 328
ILE A  90
 None
 1.21A 4ll3B-1u3tA:
undetectable		 4ll3B-1u3tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 GLY A 316
ALA A 317
PHE A 266
ALA A 183
VAL A 189
 None
 1.34A 4ryaA-1u3tA:
undetectable		 4ryaA-1u3tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 PRO A 243
LEU A 200
GLY A 199
ILE A 241
VAL A 197
 None
None
NAD  A1377 (-3.5A)
None
None
 1.19A 4x3mA-1u3tA:
2.6		 4x3mA-1u3tA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 PRO A 243
LEU A 200
GLY A 199
ILE A 241
VAL A 197
 None
None
NAD  A1377 (-3.5A)
None
None
 1.26A 4x3mB-1u3tA:
2.3		 4x3mB-1u3tA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 PHE A 176
ALA A 183
VAL A 184
SER A 177
GLY A 179
 None
 1.24A 4xnxA-1u3tA:
undetectable		 4xnxA-1u3tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 PHE A 176
ALA A 183
VAL A 184
SER A 177
GLY A 179
 None
 1.38A 4xp1A-1u3tA:
undetectable		 4xp1A-1u3tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 ASN A 225
LYS A 226
LYS A 228
LEU A 235
 None
None
NAD  A1377 (-3.1A)
None
 1.13A 4yv5B-1u3tA:
undetectable		 4yv5B-1u3tA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 ILE A  64
VAL A  63
GLY A  66
SER A 144
PRO A  20
 None
 1.03A 5ergB-1u3tA:
7.2		 5ergB-1u3tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 ILE A  64
VAL A  63
SER A 144
PHE A 140
PRO A  20
 None
 1.21A 5ergB-1u3tA:
7.2		 5ergB-1u3tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 GLY A  98
CYH A 103
CYH A 100
 ZN  A 375 ( 4.8A)
ZN  A 375 (-2.2A)
ZN  A 375 (-2.2A)
 0.96A 5inzB-1u3tA:
undetectable		 5inzB-1u3tA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 ALA A 237
ALA A 221
ILE A 208
LEU A 205
 None
 0.57A 5jncD-1u3tA:
undetectable		 5jncD-1u3tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLY A 320
THR A 178
SER A 177
GLY A 175
 None
NAD  A1377 (-3.0A)
None
None
 0.85A 5k4pA-1u3tA:
undetectable		 5k4pA-1u3tA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 PHE A 266
THR A 190
SER A 193
VAL A 262
SER A 278
 None
 1.06A 5v1tA-1u3tA:
undetectable		 5v1tA-1u3tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		5 / 9 GLY A 121
VAL A  52
GLY A 142
PHE A 359
ILE A 355
 None
 0.95A 5vkqC-1u3tA:
undetectable
5vkqD-1u3tA:
undetectable		 5vkqC-1u3tA:
14.36
5vkqD-1u3tA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 ILE A 143
THR A  59
VAL A  58
SER A 117
 None
 1.10A 6fbvC-1u3tA:
undetectable		 6fbvC-1u3tA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLY A 175
LEU A 171
PHE A 146
PHE A  21
 None
 0.99A 6h7lA-1u3tA:
0.1		 6h7lA-1u3tA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLY A 175
LEU A 171
PHE A 146
PHE A  21
 None
 0.99A 6h7lB-1u3tA:
undetectable		 6h7lB-1u3tA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 GLY A 204
LEU A 205
GLY A  47
CYH A 174
 None
None
NAD  A1377 (-3.7A)
ZN  A 376 (-2.2A)
 0.78A 6nm4A-1u3tA:
undetectable		 6nm4A-1u3tA:
19.33